BRD-K84895041_BMY 45778_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

146 genes differentially expressed following the BRD-K84895041_BMY 45778_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
AQP3 aquaporin 3 (Gill blood group)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BEX4 brain expressed, X-linked 4
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA2 carbonic anhydrase II
CALR calreticulin
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CGRRF1 cell growth regulator with ring finger domain 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COCH cochlin
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCR4 chemokine (C-X-C motif) receptor 4
DAXX death-domain associated protein
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
FCGBP Fc fragment of IgG binding protein
FRZB frizzled-related protein
GARS glycyl-tRNA synthetase
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
GPX2 glutathione peroxidase 2
GRIA2 glutamate receptor, ionotropic, AMPA 2
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HILPDA hypoxia inducible lipid droplet-associated
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HYOU1 hypoxia up-regulated 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
JAG1 jagged 1
KCTD9 potassium channel tetramerization domain containing 9
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
KRT15 keratin 15, type I
LARP6 La ribonucleoprotein domain family, member 6
LPAR1 lysophosphatidic acid receptor 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGT1 magnesium transporter 1
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP9 matrix metallopeptidase 9
MT1M metallothionein 1M
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NPIPB3 nuclear pore complex interacting protein family, member B3
NT5E 5'-nucleotidase, ecto (CD73)
P3H2 prolyl 3-hydroxylase 2
PAM peptidylglycine alpha-amidating monooxygenase
PDIA3 protein disulfide isomerase family A, member 3
PLAU plasminogen activator, urokinase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RGCC regulator of cell cycle
RNASE4 ribonuclease, RNase A family, 4
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC38A1 solute carrier family 38, member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SOD2 superoxide dismutase 2, mitochondrial
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNIP1 TNFAIP3 interacting protein 1
TPBG trophoblast glycoprotein
TPD52 tumor protein D52
TSPAN7 tetraspanin 7
TUBB6 tubulin, beta 6 class V
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
WBP5 WW domain binding protein 5
XBP1 X-box binding protein 1
YIPF6 Yip1 domain family, member 6
ZNF160 zinc finger protein 160
ZNF395 zinc finger protein 395
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANXA3 annexin A3
CALD1 caldesmon 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CLEC11A C-type lectin domain family 11, member A
COL9A3 collagen, type IX, alpha 3
ERBB3 erb-b2 receptor tyrosine kinase 3
ETV1 ets variant 1
F5 coagulation factor V (proaccelerin, labile factor)
FBLN1 fibulin 1
GNAS GNAS complex locus
HOPX HOP homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI30 interferon, gamma-inducible protein 30
IPW imprinted in Prader-Willi syndrome (non-protein coding)
JADE1 jade family PHD finger 1
JADE2 jade family PHD finger 2
KIAA1033 KIAA1033
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LTA4H leukotriene A4 hydrolase
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MARCKSL1 MARCKS-like 1
MEIS1 Meis homeobox 1
MGLL monoglyceride lipase
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NPC2 Niemann-Pick disease, type C2
PEBP1 phosphatidylethanolamine binding protein 1
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
QDPR quinoid dihydropteridine reductase
RAB4A RAB4A, member RAS oncogene family
SCYL3 SCY1-like 3 (S. cerevisiae)
SELL selectin L
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SRSF6 serine/arginine-rich splicing factor 6
TLR4 toll-like receptor 4
TMEM2 transmembrane protein 2
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UBL3 ubiquitin-like 3