BRD-K84450674_-666_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

58 genes differentially expressed following the BRD-K84450674_-666_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ACSL3 acyl-CoA synthetase long-chain family member 3
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ASNS asparagine synthetase (glutamine-hydrolyzing)
C14ORF1 chromosome 14 open reading frame 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
ELOVL5 ELOVL fatty acid elongase 5
ELOVL6 ELOVL fatty acid elongase 6
F3 coagulation factor III (thromboplastin, tissue factor)
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
GPRC5A G protein-coupled receptor, class C, group 5, member A
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGP matrix Gla protein
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC5B mucin 5B, oligomeric mucus/gel-forming
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NNMT nicotinamide N-methyltransferase
NSDHL NAD(P) dependent steroid dehydrogenase-like
PBX1 pre-B-cell leukemia homeobox 1
PDIA3 protein disulfide isomerase family A, member 3
S100A14 S100 calcium binding protein A14
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SQLE squalene epoxidase
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TPD52L1 tumor protein D52-like 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
CLC Charcot-Leyden crystal galectin
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SDC2 syndecan 2
TDO2 tryptophan 2,3-dioxygenase
TMEM45A transmembrane protein 45A