BRD-K84450674_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

113 genes differentially expressed following the BRD-K84450674_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ANXA6 annexin A6
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHMP4A charged multivesicular body protein 4A
CNN3 calponin 3, acidic
CST4 cystatin S
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
DPP4 dipeptidyl-peptidase 4
DPYSL3 dihydropyrimidinase-like 3
DUSP1 dual specificity phosphatase 1
EXT1 exostosin glycosyltransferase 1
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM13A family with sequence similarity 13, member A
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
IER3 immediate early response 3
INSIG1 insulin induced gene 1
IRF9 interferon regulatory factor 9
ITM2C integral membrane protein 2C
KRT18 keratin 18, type I
KRT81 keratin 81, type II
LAPTM5 lysosomal protein transmembrane 5
LOC100505650 uncharacterized LOC100505650
LXN latexin
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1B microtubule-associated protein 1B
MAP7 microtubule-associated protein 7
MCAM melanoma cell adhesion molecule
MKNK1 MAP kinase interacting serine/threonine kinase 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MSMO1 methylsterol monooxygenase 1
MT1M metallothionein 1M
NDRG1 N-myc downstream regulated 1
NEFL neurofilament, light polypeptide
NNMT nicotinamide N-methyltransferase
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTS neurotensin
NUCB2 nucleobindin 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLIN2 perilipin 2
PRKCB protein kinase C, beta
PTPRO protein tyrosine phosphatase, receptor type, O
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RHOB ras homolog family member B
RTN2 reticulon 2
SCG2 secretogranin II
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A2 solute carrier family 38, member 2
SOCS2 suppressor of cytokine signaling 2
STMN2 stathmin 2
SV2A synaptic vesicle glycoprotein 2A
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPD52L1 tumor protein D52-like 1
TPP1 tripeptidyl peptidase I
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VCAN versican

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ASPN asporin
ATF5 activating transcription factor 5
CAB39 calcium binding protein 39
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCND1 cyclin D1
CXCL13 chemokine (C-X-C motif) ligand 13
EVL Enah/Vasp-like
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IL1RN interleukin 1 receptor antagonist
IRS2 insulin receptor substrate 2
KLF4 Kruppel-like factor 4 (gut)
KLK11 kallikrein-related peptidase 11
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
LPL lipoprotein lipase
LSR lipolysis stimulated lipoprotein receptor
PDGFA platelet-derived growth factor alpha polypeptide
PFN2 profilin 2
POSTN periostin, osteoblast specific factor
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLPI secretory leukocyte peptidase inhibitor
SPRR1B small proline-rich protein 1B
TBX2 T-box 2