BRD-K83972459_-666_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

165 genes differentially expressed following the BRD-K83972459_-666_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
AIM1 absent in melanoma 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ALB albumin
ANGPTL2 angiopoietin-like 2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BSG basigin (Ok blood group)
C14ORF132 chromosome 14 open reading frame 132
C9ORF16 chromosome 9 open reading frame 16
CCNG2 cyclin G2
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHGB chromogranin B
CLDN3 claudin 3
COG2 component of oligomeric golgi complex 2
DHCR7 7-dehydrocholesterol reductase
DUSP14 dual specificity phosphatase 14
EDNRB endothelin receptor type B
EIF4A2 eukaryotic translation initiation factor 4A2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOXN3 forkhead box N3
GAGE3 G antigen 3
GNS glucosamine (N-acetyl)-6-sulfatase
GPNMB glycoprotein (transmembrane) nmb
GSDMB gasdermin B
H2BFS H2B histone family, member S (pseudogene)
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HK2 hexokinase 2
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI6 interferon, alpha-inducible protein 6
IL13RA1 interleukin 13 receptor, alpha 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INSIG1 insulin induced gene 1
IPO13 importin 13
KDM4B lysine (K)-specific demethylase 4B
KIAA0226L KIAA0226-like
LAMP2 lysosomal-associated membrane protein 2
MGP matrix Gla protein
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
MSMO1 methylsterol monooxygenase 1
NEBL nebulette
NEU1 sialidase 1 (lysosomal sialidase)
NMU neuromedin U
NT5E 5'-nucleotidase, ecto (CD73)
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PSAP prosaposin
QPCT glutaminyl-peptide cyclotransferase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
REG1A regenerating islet-derived 1 alpha
RNMT RNA (guanine-7-) methyltransferase
RRAGC Ras-related GTP binding C
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SMYD3 SET and MYND domain containing 3
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
SULF1 sulfatase 1
TIMP3 TIMP metallopeptidase inhibitor 3
TM7SF2 transmembrane 7 superfamily member 2
TMEM5 transmembrane protein 5
TNC tenascin C
TNNT1 troponin T type 1 (skeletal, slow)
TPP1 tripeptidyl peptidase I
TRIB2 tribbles pseudokinase 2
TST thiosulfate sulfurtransferase (rhodanese)
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADGRL2 adhesion G protein-coupled receptor L2
ALCAM activated leukocyte cell adhesion molecule
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA1 annexin A1
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ATF1 activating transcription factor 1
AXL AXL receptor tyrosine kinase
BICC1 BicC family RNA binding protein 1
C7 complement component 7
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CEP57 centrosomal protein 57kDa
CHL1 cell adhesion molecule L1-like
COL4A5 collagen, type IV, alpha 5
CP ceruloplasmin (ferroxidase)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPYD dihydropyrimidine dehydrogenase
DUSP1 dual specificity phosphatase 1
EDN1 endothelin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
EMP3 epithelial membrane protein 3
EREG epiregulin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FHL2 four and a half LIM domains 2
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FOSL1 FOS-like antigen 1
GBP1 guanylate binding protein 1, interferon-inducible
GPR171 G protein-coupled receptor 171
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HOXB2 homeobox B2
HOXB7 homeobox B7
IGKV1-5 immunoglobulin kappa variable 1-5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KLF6 Kruppel-like factor 6
KRT7 keratin 7, type II
LAPTM5 lysosomal protein transmembrane 5
LPAR1 lysophosphatidic acid receptor 1
LTF lactotransferrin
MECOM MDS1 and EVI1 complex locus
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRPS2 mitochondrial ribosomal protein S2
MSLN mesothelin
NBN nibrin
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
PBX1 pre-B-cell leukemia homeobox 1
PDE4B phosphodiesterase 4B, cAMP-specific
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PLAC8 placenta-specific 8
PLAGL1 pleiomorphic adenoma gene-like 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PPAP2C phosphatidic acid phosphatase type 2C
PTX3 pentraxin 3, long
RAD51AP1 RAD51 associated protein 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RDX radixin
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SORBS3 sorbin and SH3 domain containing 3
SRGN serglycin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCERG1 transcription elongation regulator 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UPK1B uroplakin 1B
VCAM1 vascular cell adhesion molecule 1