BRD-K83963101_MLN-8054_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-K83963101_MLN-8054_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASS1 argininosuccinate synthase 1
ATMIN ATM interactor
C6ORF62 chromosome 6 open reading frame 62
CCNB2 cyclin B2
CNOT4 CCR4-NOT transcription complex, subunit 4
COL9A3 collagen, type IX, alpha 3
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DMD dystrophin
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
ELL2 elongation factor, RNA polymerase II, 2
FGF13 fibroblast growth factor 13
FST follistatin
FXYD5 FXYD domain containing ion transport regulator 5
GRWD1 glutamate-rich WD repeat containing 1
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
LPIN1 lipin 1
LPL lipoprotein lipase
MAGEA1 melanoma antigen family A1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MYO1B myosin IB
NLRP2 NLR family, pyrin domain containing 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
POSTN periostin, osteoblast specific factor
RBMS1 RNA binding motif, single stranded interacting protein 1
SATB2 SATB homeobox 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORBS3 sorbin and SH3 domain containing 3
SPP1 secreted phosphoprotein 1
TFRC transferrin receptor
TSPYL5 TSPY-like 5
XIST X inactive specific transcript (non-protein coding)
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
AGR2 anterior gradient 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALOX15B arachidonate 15-lipoxygenase, type B
ANO1 anoctamin 1, calcium activated chloride channel
ASRGL1 asparaginase like 1
CCDC85B coiled-coil domain containing 85B
CLGN calmegin
CSTA cystatin A (stefin A)
CTSH cathepsin H
CYB5A cytochrome b5 type A (microsomal)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
FGL2 fibrinogen-like 2
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FOXA1 forkhead box A1
FXYD3 FXYD domain containing ion transport regulator 3
GPX2 glutathione peroxidase 2
GSAP gamma-secretase activating protein
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IGHM immunoglobulin heavy constant mu
LYZ lysozyme
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MBP myelin basic protein
MLPH melanophilin
MSMB microseminoprotein, beta-
MUC4 mucin 4, cell surface associated
NKG7 natural killer cell granule protein 7
PAN2 PAN2 poly(A) specific ribonuclease subunit
PLAC8 placenta-specific 8
RNASE4 ribonuclease, RNase A family, 4
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SPAG16 sperm associated antigen 16
SPDEF SAM pointed domain containing ETS transcription factor
SPON2 spondin 2, extracellular matrix protein
TARP TCR gamma alternate reading frame protein
TMEM176B transmembrane protein 176B
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TP53TG1 TP53 target 1 (non-protein coding)
TSPAN1 tetraspanin 1
VNN1 vanin 1
WFDC2 WAP four-disulfide core domain 2
YBX3 Y box binding protein 3
ZNF589 zinc finger protein 589