BRD-K83963101_MLN-8054_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-K83963101_MLN-8054_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADORA2B adenosine A2b receptor
AIM1 absent in melanoma 1
AIM2 absent in melanoma 2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA5 annexin A5
APOD apolipoprotein D
BASP1 brain abundant, membrane attached signal protein 1
BEX1 brain expressed, X-linked 1
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHGB chromogranin B
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYBB cytochrome b-245, beta polypeptide
DACH1 dachshund family transcription factor 1
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSC2 desmocollin 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELANE elastase, neutrophil expressed
F13A1 coagulation factor XIII, A1 polypeptide
FDXR ferredoxin reductase
FGF13 fibroblast growth factor 13
FOSL1 FOS-like antigen 1
GATA6 GATA binding protein 6
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPB8 heat shock 22kDa protein 8
IGHM immunoglobulin heavy constant mu
IRS1 insulin receptor substrate 1
KDM4B lysine (K)-specific demethylase 4B
KRT17 keratin 17, type I
KRT23 keratin 23, type I
KYNU kynureninase
LINC00341 long intergenic non-protein coding RNA 341
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MEF2C myocyte enhancer factor 2C
MIR22HG MIR22 host gene
MNDA myeloid cell nuclear differentiation antigen
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MTSS1 metastasis suppressor 1
NPY1R neuropeptide Y receptor Y1
OLFM4 olfactomedin 4
PLSCR3 phospholipid scramblase 3
PMEPA1 prostate transmembrane protein, androgen induced 1
PRKCZ protein kinase C, zeta
PRR7 proline rich 7 (synaptic)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RND3 Rho family GTPase 3
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100A2 S100 calcium binding protein A2
S100A9 S100 calcium binding protein A9
SELL selectin L
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SNAI2 snail family zinc finger 2
SPRR1A small proline-rich protein 1A
SUSD4 sushi domain containing 4
SVIL supervillin
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBX3 T-box 3
TPM1 tropomyosin 1 (alpha)
TRIM16 tripartite motif containing 16
TRIM22 tripartite motif containing 22
VDAC1 voltage-dependent anion channel 1
YBX1 Y box binding protein 1
ZMYND8 zinc finger, MYND-type containing 8

decreased expression

Symbol Name
AQP1 aquaporin 1 (Colton blood group)
AQP3 aquaporin 3 (Gill blood group)
CCNF cyclin F
CDK1 cyclin-dependent kinase 1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
COPS7A COP9 signalosome subunit 7A
CPD carboxypeptidase D
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL14 chemokine (C-X-C motif) ligand 14
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
EIF1AX eukaryotic translation initiation factor 1A, X-linked
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FBXL12 F-box and leucine-rich repeat protein 12
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
FOLR1 folate receptor 1 (adult)
GREM1 gremlin 1, DAN family BMP antagonist
GUSBP11 glucuronidase, beta pseudogene 11
H2AFV H2A histone family, member V
HELLS helicase, lymphoid-specific
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGKV4-1 immunoglobulin kappa variable 4-1
IGLL1 immunoglobulin lambda-like polypeptide 1
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
LDHB lactate dehydrogenase B
MBP myelin basic protein
MELK maternal embryonic leucine zipper kinase
MGLL monoglyceride lipase
NREP neuronal regeneration related protein
PDLIM1 PDZ and LIM domain 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RAD51AP1 RAD51 associated protein 1
RGCC regulator of cell cycle
SIVA1 SIVA1, apoptosis-inducing factor
SKP1 S-phase kinase-associated protein 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SUZ12 SUZ12 polycomb repressive complex 2 subunit
TAGLN2 transgelin 2
TEX30 testis expressed 30
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN6 tetraspanin 6
VGLL4 vestigial-like family member 4
ZWINT ZW10 interacting kinetochore protein