BRD-K83963101_MLN-8054_MCF7_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

69 genes differentially expressed following the BRD-K83963101_MLN-8054_MCF7_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACADVL acyl-CoA dehydrogenase, very long chain
ACSL1 acyl-CoA synthetase long-chain family member 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AQP3 aquaporin 3 (Gill blood group)
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ASPH aspartate beta-hydroxylase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BASP1 brain abundant, membrane attached signal protein 1
CPM carboxypeptidase M
CREB1 cAMP responsive element binding protein 1
CTSZ cathepsin Z
DACH1 dachshund family transcription factor 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DST dystonin
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FBN2 fibrillin 2
FHL1 four and a half LIM domains 1
FKBP11 FK506 binding protein 11, 19 kDa
FZD7 frizzled class receptor 7
G0S2 G0/G1 switch 2
GCLC glutamate-cysteine ligase, catalytic subunit
GSN gelsolin
HLA-B major histocompatibility complex, class I, B
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
LMO3 LIM domain only 3 (rhombotin-like 2)
MFAP5 microfibrillar associated protein 5
MVP major vault protein
NPY neuropeptide Y
OXTR oxytocin receptor
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
SDC2 syndecan 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFRP1 secreted frizzled-related protein 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SOX11 SRY (sex determining region Y)-box 11
STC2 stanniocalcin 2
TCL1A T-cell leukemia/lymphoma 1A
TKT transketolase
TOP1 topoisomerase (DNA) I
VCAN versican
ZMAT3 zinc finger, matrin-type 3
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADIRF adipogenesis regulatory factor
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CLDN10 claudin 10
CLEC11A C-type lectin domain family 11, member A
CRABP1 cellular retinoic acid binding protein 1
CYCS cytochrome c, somatic
DLK1 delta-like 1 homolog (Drosophila)
GTPBP8 GTP-binding protein 8 (putative)
HINT1 histidine triad nucleotide binding protein 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
MAOB monoamine oxidase B
MPO myeloperoxidase
MYO5C myosin VC
NCK1 NCK adaptor protein 1
NVL nuclear VCP-like
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PXMP2 peroxisomal membrane protein 2, 22kDa
SEPW1 selenoprotein W, 1
SKP1 S-phase kinase-associated protein 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
VCAM1 vascular cell adhesion molecule 1
VDAC1 voltage-dependent anion channel 1