BRD-K83963101_MLN-8054_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-K83963101_MLN-8054_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACBD3 acyl-CoA binding domain containing 3
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
BAX BCL2-associated X protein
CDC42 cell division cycle 42
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLIC1 chloride intracellular channel 1
CNPY3 canopy FGF signaling regulator 3
CTSZ cathepsin Z
EFNB2 ephrin-B2
EREG epiregulin
FOXG1 forkhead box G1
G0S2 G0/G1 switch 2
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX3 glutathione peroxidase 3
IL6ST interleukin 6 signal transducer
JADE2 jade family PHD finger 2
JUND jun D proto-oncogene
KLK6 kallikrein-related peptidase 6
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
LXN latexin
MELK maternal embryonic leucine zipper kinase
MX1 MX dynamin-like GTPase 1
MYO6 myosin VI
NINJ2 ninjurin 2
NRIP1 nuclear receptor interacting protein 1
OSBPL3 oxysterol binding protein-like 3
PELI1 pellino E3 ubiquitin protein ligase 1
PSD3 pleckstrin and Sec7 domain containing 3
PTX3 pentraxin 3, long
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS27L ribosomal protein S27-like
SC5D sterol-C5-desaturase
SESN1 sestrin 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SOX9 SRY (sex determining region Y)-box 9
TACSTD2 tumor-associated calcium signal transducer 2
TIGAR TP53 induced glycolysis regulatory phosphatase
TIMP1 TIMP metallopeptidase inhibitor 1
TM4SF1 transmembrane 4 L six family member 1
TM9SF2 transmembrane 9 superfamily member 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
ZMAT3 zinc finger, matrin-type 3
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALAS1 5'-aminolevulinate synthase 1
AOX1 aldehyde oxidase 1
ASS1 argininosuccinate synthase 1
CA2 carbonic anhydrase II
CCL5 chemokine (C-C motif) ligand 5
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
COL15A1 collagen, type XV, alpha 1
CRABP1 cellular retinoic acid binding protein 1
DCXR dicarbonyl/L-xylulose reductase
DLX2 distal-less homeobox 2
DMD dystrophin
FMO3 flavin containing monooxygenase 3
GJA1 gap junction protein, alpha 1, 43kDa
GRWD1 glutamate-rich WD repeat containing 1
HBB hemoglobin, beta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
KIF20A kinesin family member 20A
KRCC1 lysine-rich coiled-coil 1
MATN2 matrilin 2
MMP12 matrix metallopeptidase 12
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NRN1 neuritin 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RNH1 ribonuclease/angiogenin inhibitor 1
S100A8 S100 calcium binding protein A8
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SNX7 sorting nexin 7
TMEM47 transmembrane protein 47
TRD T cell receptor delta locus
TXNL4B thioredoxin-like 4B
WNT5A wingless-type MMTV integration site family, member 5A