BRD-K83963101_MLN-8054_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

78 genes differentially expressed following the BRD-K83963101_MLN-8054_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
C4BPA complement component 4 binding protein, alpha
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEMIP cell migration inducing protein, hyaluronan binding
CHEK2 checkpoint kinase 2
CKS2 CDC28 protein kinase regulatory subunit 2
CSRP2 cysteine and glycine-rich protein 2
ENO1 enolase 1, (alpha)
EPHB3 EPH receptor B3
FABP1 fatty acid binding protein 1, liver
FZD7 frizzled class receptor 7
IL7R interleukin 7 receptor
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LPAR1 lysophosphatidic acid receptor 1
LY75 lymphocyte antigen 75
MMP12 matrix metallopeptidase 12
NEK2 NIMA-related kinase 2
PDGFD platelet derived growth factor D
PLK1 polo-like kinase 1
RPL39L ribosomal protein L39-like
RPS11 ribosomal protein S11
SELL selectin L
STAR steroidogenic acute regulatory protein
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TPM1 tropomyosin 1 (alpha)
TUBB6 tubulin, beta 6 class V
UBE2S ubiquitin-conjugating enzyme E2S
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCY2 adenylate cyclase 2 (brain)
AKR1C3 aldo-keto reductase family 1, member C3
ARHGAP29 Rho GTPase activating protein 29
ASPN asporin
ASS1 argininosuccinate synthase 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BCHE butyrylcholinesterase
BMP2 bone morphogenetic protein 2
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COASY CoA synthase
CTSH cathepsin H
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DICER1 dicer 1, ribonuclease type III
GRB14 growth factor receptor-bound protein 14
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H1C histone cluster 1, H1c
IFRD2 interferon-related developmental regulator 2
IRS1 insulin receptor substrate 1
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOXL1 lysyl oxidase-like 1
MET MET proto-oncogene, receptor tyrosine kinase
MRPL19 mitochondrial ribosomal protein L19
MSMB microseminoprotein, beta-
NRCAM neuronal cell adhesion molecule
PCBP2 poly(rC) binding protein 2
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
S100P S100 calcium binding protein P
SEPP1 selenoprotein P, plasma, 1
SIK1 salt-inducible kinase 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SOX9 SRY (sex determining region Y)-box 9
STAB1 stabilin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TAGLN transgelin
TPR translocated promoter region, nuclear basket protein
VCAN versican