BRD-K83816656_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

70 genes differentially expressed following the BRD-K83816656_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
ARG2 arginase 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CD40 CD40 molecule, TNF receptor superfamily member 5
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CRABP2 cellular retinoic acid binding protein 2
DDIT4 DNA-damage-inducible transcript 4
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EIF5A eukaryotic translation initiation factor 5A
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
KDM3A lysine (K)-specific demethylase 3A
KRT18 keratin 18, type I
KRT7 keratin 7, type II
KRT8 keratin 8, type II
LDOC1 leucine zipper, down-regulated in cancer 1
MEST mesoderm specific transcript
MLPH melanophilin
MTMR11 myotubularin related protein 11
NIT1 nitrilase 1
PLIN2 perilipin 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
QPCT glutaminyl-peptide cyclotransferase
RPL38 ribosomal protein L38
SCGB1D2 secretoglobin, family 1D, member 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
TMEM123 transmembrane protein 123
TPD52L1 tumor protein D52-like 1
TPM2 tropomyosin 2 (beta)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)

decreased expression

Symbol Name
AKAP8 A kinase (PRKA) anchor protein 8
CASP3 caspase 3, apoptosis-related cysteine peptidase
DACH1 dachshund family transcription factor 1
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHA3 EPH receptor A3
FST follistatin
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPM6B glycoprotein M6B
HDAC9 histone deacetylase 9
HOXA5 homeobox A5
IL1R2 interleukin 1 receptor, type II
MARCKS myristoylated alanine-rich protein kinase C substrate
PLTP phospholipid transfer protein
PPAP2B phosphatidic acid phosphatase type 2B
PTN pleiotrophin
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SNX11 sorting nexin 11
SNX7 sorting nexin 7
SPRR1B small proline-rich protein 1B
SPRY2 sprouty homolog 2 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
TCF4 transcription factor 4
TIMP3 TIMP metallopeptidase inhibitor 3
TSPAN3 tetraspanin 3
ZIC1 Zic family member 1