BRD-K83778500_AT-CSC-18 BRD-K01121114_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

226 genes differentially expressed following the BRD-K83778500_AT-CSC-18 BRD-K01121114_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CD24 CD24 molecule
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLDND1 claudin domain containing 1
CRELD2 cysteine-rich with EGF-like domains 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSG3 desmoglein 3
DUSP1 dual specificity phosphatase 1
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
ECM1 extracellular matrix protein 1
EGFR epidermal growth factor receptor
EIF1 eukaryotic translation initiation factor 1
EPAS1 endothelial PAS domain protein 1
EVI2A ecotropic viral integration site 2A
F3 coagulation factor III (thromboplastin, tissue factor)
FBN2 fibrillin 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FN1 fibronectin 1
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GATAD1 GATA zinc finger domain containing 1
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GOLT1B golgi transport 1B
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRB10 growth factor receptor-bound protein 10
GTPBP2 GTP binding protein 2
HBEGF heparin-binding EGF-like growth factor
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFNGR1 interferon gamma receptor 1
IFRD1 interferon-related developmental regulator 1
IGFBP3 insulin-like growth factor binding protein 3
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
INHBA inhibin, beta A
IRF6 interferon regulatory factor 6
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
JUNB jun B proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LAMB3 laminin, beta 3
LARP6 La ribonucleoprotein domain family, member 6
LCN2 lipocalin 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MFAP5 microfibrillar associated protein 5
MIR22HG MIR22 host gene
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NAMPT nicotinamide phosphoribosyltransferase
NCF2 neutrophil cytosolic factor 2
NEBL nebulette
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
NUCB2 nucleobindin 2
OLFM4 olfactomedin 4
OPTN optineurin
PALLD palladin, cytoskeletal associated protein
PDGFA platelet-derived growth factor alpha polypeptide
PDGFC platelet derived growth factor C
PHGDH phosphoglycerate dehydrogenase
PI3 peptidase inhibitor 3, skin-derived
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
RAB9A RAB9A, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RIOK3 RIO kinase 3
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERINC3 serine incorporator 3
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLPI secretory leukocyte peptidase inhibitor
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
SRGN serglycin
SULF1 sulfatase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM176B transmembrane protein 176B
TNIP1 TNFAIP3 interacting protein 1
TRIB3 tribbles pseudokinase 3
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
VGLL4 vestigial-like family member 4
WARS tryptophanyl-tRNA synthetase
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
XPOT exportin, tRNA
YPEL5 yippee-like 5 (Drosophila)
ZC3H12A zinc finger CCCH-type containing 12A
ZIC1 Zic family member 1

decreased expression

Symbol Name
AK4 adenylate kinase 4
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
B3GNT1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C7 complement component 7
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CDC25A cell division cycle 25A
CDK1 cyclin-dependent kinase 1
CENPF centromere protein F, 350/400kDa
CIT citron rho-interacting serine/threonine kinase
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNM1 dynamin 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F2 E2F transcription factor 2
ESR1 estrogen receptor 1
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GAL galanin/GMAP prepropeptide
GINS2 GINS complex subunit 2 (Psf2 homolog)
GREB1 growth regulation by estrogen in breast cancer 1
GTSE1 G-2 and S-phase expressed 1
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
ICMT isoprenylcysteine carboxyl methyltransferase
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF20A kinesin family member 20A
LAMP5 lysosomal-associated membrane protein family, member 5
LAPTM4B lysosomal protein transmembrane 4 beta
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LOC100505650 uncharacterized LOC100505650
LY6E lymphocyte antigen 6 complex, locus E
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
OBSL1 obscurin-like 1
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PEBP1 phosphatidylethanolamine binding protein 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAD54B RAD54 homolog B (S. cerevisiae)
RBPMS RNA binding protein with multiple splicing
RFC3 replication factor C (activator 1) 3, 38kDa
SHCBP1 SHC SH2-domain binding protein 1
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SPC25 SPC25, NDC80 kinetochore complex component
STMN1 stathmin 1
SUMO3 small ubiquitin-like modifier 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFDP1 transcription factor Dp-1
TMEM97 transmembrane protein 97
TMPO thymopoietin
TNS1 tensin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIP13 thyroid hormone receptor interactor 13
TYMS thymidylate synthetase