BRD-K83778500_AT-CSC-18 BRD-K01121114_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

189 genes differentially expressed following the BRD-K83778500_AT-CSC-18 BRD-K01121114_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CA2 carbonic anhydrase II
CALR calreticulin
CD200 CD200 molecule
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLC Charcot-Leyden crystal galectin
CRABP2 cellular retinoic acid binding protein 2
ELANE elastase, neutrophil expressed
EXT1 exostosin glycosyltransferase 1
HEPH hephaestin
HIST1H2BG histone cluster 1, H2bg
HOMER3 homer scaffolding protein 3
IGFBP5 insulin-like growth factor binding protein 5
KLF6 Kruppel-like factor 6
LAMP1 lysosomal-associated membrane protein 1
LOXL2 lysyl oxidase-like 2
MPO myeloperoxidase
NCAM1 neural cell adhesion molecule 1
NELL2 NEL-like 2 (chicken)
PDE8B phosphodiesterase 8B
PDIA3 protein disulfide isomerase family A, member 3
PRR15L proline rich 15-like
PRTN3 proteinase 3
PXDN peroxidasin
RAB25 RAB25, member RAS oncogene family
RAB31 RAB31, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SMC1A structural maintenance of chromosomes 1A
SPON2 spondin 2, extracellular matrix protein
SPRR3 small proline-rich protein 3
TCF4 transcription factor 4
TNNT1 troponin T type 1 (skeletal, slow)
TP53I3 tumor protein p53 inducible protein 3
TSPAN1 tetraspanin 1
TSPAN7 tetraspanin 7
TUBB2A tubulin, beta 2A class IIa
UBQLN2 ubiquilin 2
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AGTR1 angiotensin II receptor, type 1
AHR aryl hydrocarbon receptor
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AOX1 aldehyde oxidase 1
APOD apolipoprotein D
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARMCX2 armadillo repeat containing, X-linked 2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASS1 argininosuccinate synthase 1
ATF1 activating transcription factor 1
BET1 Bet1 golgi vesicular membrane trafficking protein
C1QB complement component 1, q subcomponent, B chain
C3 complement component 3
C5ORF22 chromosome 5 open reading frame 22
C5ORF28 chromosome 5 open reading frame 28
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CDK4 cyclin-dependent kinase 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPU centromere protein U
CEP57 centrosomal protein 57kDa
CETN3 centrin, EF-hand protein, 3
CFB complement factor B
CHEK1 checkpoint kinase 1
CHMP4A charged multivesicular body protein 4A
CLIC5 chloride intracellular channel 5
CP ceruloplasmin (ferroxidase)
CPM carboxypeptidase M
CRYAB crystallin, alpha B
CRYZ crystallin, zeta (quinone reductase)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLD dihydrolipoamide dehydrogenase
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DYNLT3 dynein, light chain, Tctex-type 3
EAPP E2F-associated phosphoprotein
EBNA1BP2 EBNA1 binding protein 2
EDNRB endothelin receptor type B
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ERBB3 erb-b2 receptor tyrosine kinase 3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP4 fatty acid binding protein 4, adipocyte
FABP7 fatty acid binding protein 7, brain
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FOSL2 FOS-like antigen 2
FZD6 frizzled class receptor 6
G0S2 G0/G1 switch 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GBP1 guanylate binding protein 1, interferon-inducible
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GOLPH3 golgi phosphoprotein 3 (coat-protein)
GOLT1B golgi transport 1B
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX3 glutathione peroxidase 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA1A heat shock 70kDa protein 1A
HSPB11 heat shock protein family B (small), member 11
IGFBP7 insulin-like growth factor binding protein 7
IL13RA2 interleukin 13 receptor, alpha 2
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
KDM5D lysine (K)-specific demethylase 5D
KRT14 keratin 14, type I
KYNU kynureninase
LACTB2 lactamase, beta 2
LGALS3 lectin, galactoside-binding, soluble, 3
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2B methionine adenosyltransferase II, beta
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MIS12 MIS12 kinetochore complex component
MPZL1 myelin protein zero-like 1
MRPS30 mitochondrial ribosomal protein S30
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
NMU neuromedin U
NNT nicotinamide nucleotide transhydrogenase
NPY1R neuropeptide Y receptor Y1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
NUAK1 NUAK family, SNF1-like kinase, 1
OLFM4 olfactomedin 4
OXCT1 3-oxoacid CoA transferase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAIP1 poly(A) binding protein interacting protein 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG10 paternally expressed 10
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PKP2 plakophilin 2
PLAGL1 pleiomorphic adenoma gene-like 1
PRKCI protein kinase C, iota
PRPF4 pre-mRNA processing factor 4
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PUS7 pseudouridylate synthase 7 (putative)
RAD1 RAD1 checkpoint DNA exonuclease
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RECQL RecQ helicase-like
RFK riboflavin kinase
RGS1 regulator of G-protein signaling 1
RNF167 ring finger protein 167
RRP1B ribosomal RNA processing 1B
S100A13 S100 calcium binding protein A13
SC5D sterol-C5-desaturase
SGK1 serum/glucocorticoid regulated kinase 1
SLC16A6 solute carrier family 16, member 6
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOAT1 sterol O-acyltransferase 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STX1A syntaxin 1A (brain)
SYNM synemin, intermediate filament protein
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM165 transmembrane protein 165
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN13 tetraspanin 13
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae)
UBE3B ubiquitin protein ligase E3B
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
XPO1 exportin 1
ZMYM2 zinc finger, MYM-type 2