BRD-K83670234_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

231 genes differentially expressed following the BRD-K83670234_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AIDA axin interactor, dorsalization associated
AIF1 allograft inflammatory factor 1
APLP2 amyloid beta (A4) precursor-like protein 2
AQP9 aquaporin 9
AREG amphiregulin
ARG1 arginase 1
ARHGAP29 Rho GTPase activating protein 29
ARL4C ADP-ribosylation factor-like 4C
BEX4 brain expressed, X-linked 4
BSG basigin (Ok blood group)
BTG3 BTG family, member 3
CAMP cathelicidin antimicrobial peptide
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD47 CD47 molecule
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDO1 cysteine dioxygenase type 1
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
CKB creatine kinase, brain
CLC Charcot-Leyden crystal galectin
CLDN3 claudin 3
CLEC2B C-type lectin domain family 2, member B
CLEC5A C-type lectin domain family 5, member A
CLIC5 chloride intracellular channel 5
COL1A2 collagen, type I, alpha 2
CORO1A coronin, actin binding protein, 1A
CXADR coxsackie virus and adenovirus receptor
CXCL8 chemokine (C-X-C motif) ligand 8
DEFA4 defensin, alpha 4, corticostatin
DPYSL3 dihydropyrimidinase-like 3
DSP desmoplakin
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EXPH5 exophilin 5
FBN1 fibrillin 1
FBN2 fibrillin 2
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
FHL1 four and a half LIM domains 1
FKBP1A FK506 binding protein 1A, 12kDa
GJA1 gap junction protein, alpha 1, 43kDa
GPX3 glutathione peroxidase 3
GSTA1 glutathione S-transferase alpha 1
GYPC glycophorin C (Gerbich blood group)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-B major histocompatibility complex, class I, B
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXB2 homeobox B2
HRSP12 heat-responsive protein 12
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFT57 intraflagellar transport 57
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ISG15 ISG15 ubiquitin-like modifier
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
LAPTM4B lysosomal protein transmembrane 4 beta
LAPTM5 lysosomal protein transmembrane 5
LCN2 lipocalin 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTA4H leukotriene A4 hydrolase
MAOB monoamine oxidase B
MEF2C myocyte enhancer factor 2C
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MN1 meningioma (disrupted in balanced translocation) 1
NEFL neurofilament, light polypeptide
NELL2 NEL-like 2 (chicken)
NMU neuromedin U
P3H2 prolyl 3-hydroxylase 2
PCSK6 proprotein convertase subtilisin/kexin type 6
PDIA6 protein disulfide isomerase family A, member 6
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG10 paternally expressed 10
PFKM phosphofructokinase, muscle
PGK1 phosphoglycerate kinase 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRAME preferentially expressed antigen in melanoma
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTRF polymerase I and transcript release factor
QPCT glutaminyl-peptide cyclotransferase
RGCC regulator of cell cycle
S100A12 S100 calcium binding protein A12
SCG5 secretogranin V
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC2 syndecan 2
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEPT2 septin 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SESN1 sestrin 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLPI secretory leukocyte peptidase inhibitor
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPON1 spondin 1, extracellular matrix protein
SST somatostatin
TFPI2 tissue factor pathway inhibitor 2
TFR2 transferrin receptor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM123 transmembrane protein 123
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM230 transmembrane protein 230
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TPMT thiopurine S-methyltransferase
TPP1 tripeptidyl peptidase I
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VIM vimentin
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
AAK1 AP2 associated kinase 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AKAP12 A kinase (PRKA) anchor protein 12
ANKRD17 ankyrin repeat domain 17
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4A ADP-ribosylation factor-like 4A
AURKA aurora kinase A
AXIN1 axin 1
BLM Bloom syndrome, RecQ helicase-like
CA12 carbonic anhydrase XII
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNF cyclin F
CD58 CD58 molecule
CDC25A cell division cycle 25A
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEP350 centrosomal protein 350kDa
CHD1 chromodomain helicase DNA binding protein 1
CHD9 chromodomain helicase DNA binding protein 9
CKS2 CDC28 protein kinase regulatory subunit 2
CNOT4 CCR4-NOT transcription complex, subunit 4
DCLRE1C DNA cross-link repair 1C
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ELF1 E74-like factor 1 (ets domain transcription factor)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GOLGA8A golgin A8 family, member A
GRWD1 glutamate-rich WD repeat containing 1
GTPBP8 GTP-binding protein 8 (putative)
HMOX1 heme oxygenase 1
HOXA5 homeobox A5
HOXC6 homeobox C6
HSPA2 heat shock 70kDa protein 2
HSPH1 heat shock 105kDa/110kDa protein 1
IGF1R insulin-like growth factor 1 receptor
INTS6 integrator complex subunit 6
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KDM5B lysine (K)-specific demethylase 5B
KEAP1 kelch-like ECH-associated protein 1
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KYNU kynureninase
LOC100272216 uncharacterized LOC100272216
LXN latexin
MAPT microtubule-associated protein tau
MAST4 microtubule associated serine/threonine kinase family member 4
MBP myelin basic protein
MCM10 minichromosome maintenance complex component 10
MED13 mediator complex subunit 13
MEPCE methylphosphate capping enzyme
MGP matrix Gla protein
MTUS1 microtubule associated tumor suppressor 1
N4BP2L2 NEDD4 binding protein 2-like 2
NCOA3 nuclear receptor coactivator 3
NPY1R neuropeptide Y receptor Y1
PCDH9 protocadherin 9
PCM1 pericentriolar material 1
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PLA2G15 phospholipase A2, group XV
PLK1 polo-like kinase 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPP1R10 protein phosphatase 1, regulatory subunit 10
PSRC1 proline/serine-rich coiled-coil 1
RABIF RAB interacting factor
RAD9A RAD9 homolog A (S. pombe)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPP38 ribonuclease P/MRP 38kDa subunit
SAMD4A sterile alpha motif domain containing 4A
SEPHS1 selenophosphate synthetase 1
SETX senataxin
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SMAD1 SMAD family member 1
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TACC2 transforming, acidic coiled-coil containing protein 2
TBL1X transducin (beta)-like 1X-linked
TBX2 T-box 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGIF1 TGFB-induced factor homeobox 1
TNPO1 transportin 1
TRIM33 tripartite motif containing 33
TSC22D2 TSC22 domain family, member 2
TSEN2 TSEN2 tRNA splicing endonuclease subunit
WIPF2 WAS/WASL interacting protein family, member 2
WSB1 WD repeat and SOCS box containing 1
ZBTB38 zinc finger and BTB domain containing 38
ZMYM2 zinc finger, MYM-type 2
ZNF131 zinc finger protein 131
ZNF652 zinc finger protein 652