BRD-K83670234_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

223 genes differentially expressed following the BRD-K83670234_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACPP acid phosphatase, prostate
ADD3 adducin 3 (gamma)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANGPTL2 angiopoietin-like 2
ANXA1 annexin A1
APOLD1 apolipoprotein L domain containing 1
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
ATRX alpha thalassemia/mental retardation syndrome X-linked
BHLHE40 basic helix-loop-helix family, member e40
BTG3 BTG family, member 3
CA4 carbonic anhydrase IV
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CCND2 cyclin D2
CD46 CD46 molecule, complement regulatory protein
CFD complement factor D (adipsin)
CKB creatine kinase, brain
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
COL5A2 collagen, type V, alpha 2
COLEC12 collectin sub-family member 12
COPA coatomer protein complex, subunit alpha
CPE carboxypeptidase E
CXADR coxsackie virus and adenovirus receptor
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DEFA4 defensin, alpha 4, corticostatin
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
ERBB4 erb-b2 receptor tyrosine kinase 4
EXPH5 exophilin 5
FAM198B family with sequence similarity 198, member B
FHL1 four and a half LIM domains 1
FLT1 fms-related tyrosine kinase 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FST follistatin
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA6 GATA binding protein 6
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GPR183 G protein-coupled receptor 183
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOPX HOP homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA1462 KIAA1462
LMO3 LIM domain only 3 (rhombotin-like 2)
LRRC17 leucine rich repeat containing 17
MAOA monoamine oxidase A
MDFIC MyoD family inhibitor domain containing
MEIS2 Meis homeobox 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NTS neurotensin
OLFM4 olfactomedin 4
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCP4 Purkinje cell protein 4
PDGFD platelet derived growth factor D
PEA15 phosphoprotein enriched in astrocytes 15
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLN phospholamban
PLVAP plasmalemma vesicle associated protein
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
REG3A regenerating islet-derived 3 alpha
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS5 regulator of G-protein signaling 5
SCD5 stearoyl-CoA desaturase 5
SCUBE2 signal peptide, CUB domain, EGF-like 2
SDC2 syndecan 2
SNAI2 snail family zinc finger 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SST somatostatin
ST18 suppression of tumorigenicity 18, zinc finger
STC1 stanniocalcin 1
SULF1 sulfatase 1
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TKTL1 transketolase-like 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIM2 tripartite motif containing 2
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADGRG6 adhesion G protein-coupled receptor G6
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARFIP2 ADP-ribosylation factor interacting protein 2
ARMCX6 armadillo repeat containing, X-linked 6
ARMT1 acidic residue methyltransferase 1
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BEX1 brain expressed, X-linked 1
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNF cyclin F
CDC123 cell division cycle 123
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPA centromere protein A
COMMD4 COMM domain containing 4
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSK c-src tyrosine kinase
CTSH cathepsin H
CXCL12 chemokine (C-X-C motif) ligand 12
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF5A eukaryotic translation initiation factor 5A
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
FAM134B family with sequence similarity 134, member B
FOXO3 forkhead box O3
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GSPT2 G1 to S phase transition 2
HAUS4 HAUS augmin-like complex, subunit 4
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IGHM immunoglobulin heavy constant mu
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
JMJD6 jumonji domain containing 6
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT7 keratin 7, type II
KYNU kynureninase
LAP3 leucine aminopeptidase 3
LY6E lymphocyte antigen 6 complex, locus E
MARCKS myristoylated alanine-rich protein kinase C substrate
METTL7A methyltransferase like 7A
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MRPL12 mitochondrial ribosomal protein L12
MTDH metadherin
MYH10 myosin, heavy chain 10, non-muscle
MYO6 myosin VI
NCOA3 nuclear receptor coactivator 3
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NNMT nicotinamide N-methyltransferase
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
OXLD1 oxidoreductase-like domain containing 1
PARP2 poly (ADP-ribose) polymerase 2
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POU2AF1 POU class 2 associating factor 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PROM1 prominin 1
PXDN peroxidasin
RET ret proto-oncogene
RPL36AL ribosomal protein L36a-like
RPP25 ribonuclease P/MRP 25kDa subunit
SCAND1 SCAN domain containing 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SIX1 SIX homeobox 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SNRPB2 small nuclear ribonucleoprotein polypeptide B
SNRPE small nuclear ribonucleoprotein polypeptide E
SPDEF SAM pointed domain containing ETS transcription factor
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACSTD2 tumor-associated calcium signal transducer 2
TBP TATA box binding protein
TBX2 T-box 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TES testin LIM domain protein
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPIN TIMELESS interacting protein
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP1 topoisomerase (DNA) I
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TSKU tsukushi, small leucine rich proteoglycan
TSPYL5 TSPY-like 5
TUBB tubulin, beta class I
TXLNA taxilin alpha
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VAT1 vesicle amine transport 1
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
XPO7 exportin 7
ZMYND8 zinc finger, MYND-type containing 8