BRD-K83670234_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

272 genes differentially expressed following the BRD-K83670234_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
AEBP1 AE binding protein 1
AIDA axin interactor, dorsalization associated
ALOX5 arachidonate 5-lipoxygenase
ANGPTL2 angiopoietin-like 2
AQP1 aquaporin 1 (Colton blood group)
ARL4C ADP-ribosylation factor-like 4C
ASPN asporin
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
C3ORF14 chromosome 3 open reading frame 14
CA4 carbonic anhydrase IV
CAV1 caveolin 1, caveolae protein, 22kDa
CD163 CD163 molecule
CD24 CD24 molecule
CD47 CD47 molecule
CD9 CD9 molecule
CD93 CD93 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CEP70 centrosomal protein 70kDa
CFH complement factor H
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL11A1 collagen, type XI, alpha 1
COL3A1 collagen, type III, alpha 1
CXCL10 chemokine (C-X-C motif) ligand 10
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DENND1B DENN/MADD domain containing 1B
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFL6 EGF-like-domain, multiple 6
EGLN3 egl-9 family hypoxia-inducible factor 3
EID1 EP300 interacting inhibitor of differentiation 1
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
ESM1 endothelial cell-specific molecule 1
ESRP1 epithelial splicing regulatory protein 1
EXPH5 exophilin 5
FLT1 fms-related tyrosine kinase 1
GDE1 glycerophosphodiester phosphodiesterase 1
GJA1 gap junction protein, alpha 1, 43kDa
GNG10 guanine nucleotide binding protein (G protein), gamma 10
GPM6A glycoprotein M6A
GSTA1 glutathione S-transferase alpha 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HDGFRP3 hepatoma-derived growth factor, related protein 3
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFT57 intraflagellar transport 57
IGFBP5 insulin-like growth factor binding protein 5
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITM2A integral membrane protein 2A
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KDR kinase insert domain receptor
LDOC1 leucine zipper, down-regulated in cancer 1
LRRC17 leucine rich repeat containing 17
LTBP1 latent transforming growth factor beta binding protein 1
LY96 lymphocyte antigen 96
MARCO macrophage receptor with collagenous structure
MECOM MDS1 and EVI1 complex locus
MEF2C myocyte enhancer factor 2C
MYOF myoferlin
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEBL nebulette
NUPR1 nuclear protein, transcriptional regulator, 1
P3H2 prolyl 3-hydroxylase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PECAM1 platelet/endothelial cell adhesion molecule 1
PGK1 phosphoglycerate kinase 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLVAP plasmalemma vesicle associated protein
PODXL podocalyxin-like
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCI protein kinase C, iota
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
RLN1 relaxin 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SCN3A sodium channel, voltage gated, type III alpha subunit
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SNX10 sorting nexin 10
SOX2 SRY (sex determining region Y)-box 2
SPARCL1 SPARC-like 1 (hevin)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STC1 stanniocalcin 1
SULF1 sulfatase 1
TCF21 transcription factor 21
TCF4 transcription factor 4
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM230 transmembrane protein 230
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
VTCN1 V-set domain containing T cell activation inhibitor 1
WISP2 WNT1 inducible signaling pathway protein 2
WLS wntless Wnt ligand secretion mediator
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACBD3 acyl-CoA binding domain containing 3
ACTN1 actinin, alpha 1
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ARID4B AT rich interactive domain 4B (RBP1-like)
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
BLCAP bladder cancer associated protein
BRCA1 breast cancer 1, early onset
BRD1 bromodomain containing 1
BRD3 bromodomain containing 3
BRPF1 bromodomain and PHD finger containing, 1
CCNA2 cyclin A2
CCNF cyclin F
CD79A CD79a molecule, immunoglobulin-associated alpha
CDCA4 cell division cycle associated 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2AIP CDKN2A interacting protein
CDKN3 cyclin-dependent kinase inhibitor 3
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CENPA centromere protein A
CHD1 chromodomain helicase DNA binding protein 1
CKS2 CDC28 protein kinase regulatory subunit 2
COCH cochlin
CRIP1 cysteine-rich protein 1 (intestinal)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL13 chemokine (C-X-C motif) ligand 13
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP14 dual specificity phosphatase 14
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EHD1 EH-domain containing 1
ELF1 E74-like factor 1 (ets domain transcription factor)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
F5 coagulation factor V (proaccelerin, labile factor)
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FSCN1 fascin actin-bundling protein 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GOLGA8A golgin A8 family, member A
GRWD1 glutamate-rich WD repeat containing 1
GTF2IRD1 GTF2I repeat domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HEXIM1 hexamethylene bis-acetamide inducible 1
HNRNPL heterogeneous nuclear ribonucleoprotein L
HOMER1 homer scaffolding protein 1
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IGFBP4 insulin-like growth factor binding protein 4
IGKV1-5 immunoglobulin kappa variable 1-5
INPP1 inositol polyphosphate-1-phosphatase
INTS6 integrator complex subunit 6
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JMJD6 jumonji domain containing 6
KEAP1 kelch-like ECH-associated protein 1
KIF2C kinesin family member 2C
KRT17 keratin 17, type I
LRIF1 ligand dependent nuclear receptor interacting factor 1
MALT1 MALT1 paracaspase
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MDN1 MDN1, midasin homolog (yeast)
MED13 mediator complex subunit 13
MET MET proto-oncogene, receptor tyrosine kinase
MGA MGA, MAX dimerization protein
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MMD monocyte to macrophage differentiation-associated
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSH6 mutS homolog 6
MSX1 msh homeobox 1
N4BP2L2 NEDD4 binding protein 2-like 2
NET1 neuroepithelial cell transforming 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
PDS5B PDS5 cohesin associated factor B
PHF20 PHD finger protein 20
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
POU2AF1 POU class 2 associating factor 1
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PRKCA protein kinase C, alpha
PRPF4 pre-mRNA processing factor 4
PSPC1 paraspeckle component 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RABGAP1 RAB GTPase activating protein 1
RAD9A RAD9 homolog A (S. pombe)
RBM15 RNA binding motif protein 15
RPL36AL ribosomal protein L36a-like
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRP1B ribosomal RNA processing 1B
RUNX3 runt-related transcription factor 3
S100P S100 calcium binding protein P
SCAF8 SR-related CTD-associated factor 8
SIRT1 sirtuin 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLPI secretory leukocyte peptidase inhibitor
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOX4 SRY (sex determining region Y)-box 4
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STIL SCL/TAL1 interrupting locus
STK17A serine/threonine kinase 17a
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBC1D4 TBC1 domain family, member 4
TBL1X transducin (beta)-like 1X-linked
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCP1 t-complex 1
TEFM transcription elongation factor, mitochondrial
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOB2 transducer of ERBB2, 2
TOP1 topoisomerase (DNA) I
TRAF4 TNF receptor-associated factor 4
TRIM16 tripartite motif containing 16
TRIM29 tripartite motif containing 29
TRIM32 tripartite motif containing 32
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TSPYL5 TSPY-like 5
TXLNA taxilin alpha
WAPAL wings apart-like homolog (Drosophila)
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
WTAP Wilms tumor 1 associated protein
XBP1 X-box binding protein 1
ZMYM2 zinc finger, MYM-type 2
ZNF410 zinc finger protein 410