BRD-K83336168_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-K83336168_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AQP1 aquaporin 1 (Colton blood group)
ATF3 activating transcription factor 3
CAPN2 calpain 2, (m/II) large subunit
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CES1 carboxylesterase 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CXCL10 chemokine (C-X-C motif) ligand 10
DPYSL3 dihydropyrimidinase-like 3
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
ELANE elastase, neutrophil expressed
EZR ezrin
FGG fibrinogen gamma chain
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GAS6 growth arrest-specific 6
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GUSBP11 glucuronidase, beta pseudogene 11
H2BFS H2B histone family, member S (pseudogene)
H3F3B H3 histone, family 3B (H3.3B)
HBD hemoglobin, delta
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
LAPTM5 lysosomal protein transmembrane 5
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MPO myeloperoxidase
MUC16 mucin 16, cell surface associated
OBSL1 obscurin-like 1
PDIA6 protein disulfide isomerase family A, member 6
PODXL podocalyxin-like
PRTN3 proteinase 3
PSPH phosphoserine phosphatase
RGCC regulator of cell cycle
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB1D2 secretoglobin, family 1D, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SPARCL1 SPARC-like 1 (hevin)
SRGN serglycin
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
VCAN versican
VWF von Willebrand factor
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
AGTR1 angiotensin II receptor, type 1
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
B3GNT1
BAMBI BMP and activin membrane-bound inhibitor
BIRC3 baculoviral IAP repeat containing 3
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CD24 CD24 molecule
CDK19 cyclin-dependent kinase 19
CHPT1 choline phosphotransferase 1
CHSY1 chondroitin sulfate synthase 1
CLCN3 chloride channel, voltage-sensitive 3
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
CPNE3 copine III
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CXCL14 chemokine (C-X-C motif) ligand 14
DCK deoxycytidine kinase
DCLK1 doublecortin-like kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLG5 discs, large homolog 5 (Drosophila)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FOXO3 forkhead box O3
FZD7 frizzled class receptor 7
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAS7 growth arrest-specific 7
GATA3 GATA binding protein 3
GMFB glia maturation factor, beta
GPX2 glutathione peroxidase 2
IGF1R insulin-like growth factor 1 receptor
IL1R1 interleukin 1 receptor, type I
IL6ST interleukin 6 signal transducer
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
KAT6A K(lysine) acetyltransferase 6A
KDM5D lysine (K)-specific demethylase 5D
KIF1B kinesin family member 1B
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT14 keratin 14, type I
LPGAT1 lysophosphatidylglycerol acyltransferase 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MBP myelin basic protein
MEGF9 multiple EGF-like-domains 9
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MGP matrix Gla protein
MREG melanoregulin
MUC1 mucin 1, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NAV2 neuron navigator 2
NCOA3 nuclear receptor coactivator 3
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOTCH2NL notch 2 N-terminal like
NOV nephroblastoma overexpressed
NPTN neuroplastin
NQO1 NAD(P)H dehydrogenase, quinone 1
NRIP1 nuclear receptor interacting protein 1
OSBPL8 oxysterol binding protein-like 8
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRR7 proline rich 7 (synaptic)
PTGES prostaglandin E synthase
QDPR quinoid dihydropteridine reductase
RBBP4 retinoblastoma binding protein 4
RELN reelin
RPS4Y1 ribosomal protein S4, Y-linked 1
SDC2 syndecan 2
SEC23A Sec23 homolog A (S. cerevisiae)
SF1 splicing factor 1
SIAH2 siah E3 ubiquitin protein ligase 2
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC38A1 solute carrier family 38, member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
STOM stomatin
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBX3 T-box 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TMEM100 transmembrane protein 100
TMF1 TATA element modulatory factor 1
TRAK2 trafficking protein, kinesin binding 2
TXLNA taxilin alpha
UGCG UDP-glucose ceramide glucosyltransferase
UGDH UDP-glucose 6-dehydrogenase
WWP1 WW domain containing E3 ubiquitin protein ligase 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZBTB18 zinc finger and BTB domain containing 18