BRD-K83336168_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

134 genes differentially expressed following the BRD-K83336168_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA1 annexin A1
APOD apolipoprotein D
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C3ORF14 chromosome 3 open reading frame 14
CA2 carbonic anhydrase II
CALML5 calmodulin-like 5
CAPG capping protein (actin filament), gelsolin-like
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCR2 chemokine (C-C motif) receptor 2
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD1E CD1e molecule
CD200 CD200 molecule
CD36 CD36 molecule (thrombospondin receptor)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC10A C-type lectin domain family 10, member A
CNPY3 canopy FGF signaling regulator 3
CSTA cystatin A (stefin A)
CTNND1 catenin (cadherin-associated protein), delta 1
CTSS cathepsin S
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL10 chemokine (C-X-C motif) ligand 10
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DUSP1 dual specificity phosphatase 1
EFHD1 EF-hand domain family, member D1
EGR1 early growth response 1
FBP1 fructose-1,6-bisphosphatase 1
FHL2 four and a half LIM domains 2
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FXYD2 FXYD domain containing ion transport regulator 2
H2AFX H2A histone family, member X
H2BFS H2B histone family, member S (pseudogene)
H3F3B H3 histone, family 3B (H3.3B)
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HIST1H4C histone cluster 1, H4c
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IGSF3 immunoglobulin superfamily, member 3
INHBB inhibin, beta B
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KYNU kynureninase
LGALS2 lectin, galactoside-binding, soluble, 2
LOC100505650 uncharacterized LOC100505650
MARS methionyl-tRNA synthetase
MEIS2 Meis homeobox 2
MMP7 matrix metallopeptidase 7
OBSL1 obscurin-like 1
PEA15 phosphoprotein enriched in astrocytes 15
PIP prolactin-induced protein
PPOX protoporphyrinogen oxidase
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
TFPI2 tissue factor pathway inhibitor 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TUBA1A tubulin, alpha 1a
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADRB2 adrenoceptor beta 2, surface
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BASP1 brain abundant, membrane attached signal protein 1
C8ORF4 chromosome 8 open reading frame 4
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
COL14A1 collagen, type XIV, alpha 1
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DICER1 dicer 1, ribonuclease type III
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DST dystonin
DUSP4 dual specificity phosphatase 4
EFNB2 ephrin-B2
EPHA3 EPH receptor A3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM171A1 family with sequence similarity 171, member A1
FAM65B family with sequence similarity 65, member B
FBXO21 F-box protein 21
FGF13 fibroblast growth factor 13
GAS7 growth arrest-specific 7
GPM6B glycoprotein M6B
IFI27 interferon, alpha-inducible protein 27
IGFBP5 insulin-like growth factor binding protein 5
JAG1 jagged 1
KIAA0907 KIAA0907
KIF1B kinesin family member 1B
KLC1 kinesin light chain 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LUM lumican
MAP1B microtubule-associated protein 1B
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL1 muscleblind-like splicing regulator 1
MBP myelin basic protein
MED13L mediator complex subunit 13-like
MERTK MER proto-oncogene, tyrosine kinase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MME membrane metallo-endopeptidase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIB nuclear factor I/B
NPY neuropeptide Y
NRIP1 nuclear receptor interacting protein 1
PER1 period circadian clock 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PTX3 pentraxin 3, long
S100P S100 calcium binding protein P
SEPP1 selenoprotein P, plasma, 1
SERINC5 serine incorporator 5
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SYNM synemin, intermediate filament protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM100 transmembrane protein 100
TREM1 triggering receptor expressed on myeloid cells 1
ZBTB16 zinc finger and BTB domain containing 16
ZBTB18 zinc finger and BTB domain containing 18
ZMIZ1 zinc finger, MIZ-type containing 1