BRD-K83289131_CAY10618_AGS_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

131 genes differentially expressed following the BRD-K83289131_CAY10618_AGS_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AMIGO2 adhesion molecule with Ig-like domain 2
APOLD1 apolipoprotein L domain containing 1
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BCR breakpoint cluster region
BLNK B-cell linker
C10ORF10 chromosome 10 open reading frame 10
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CDH13 cadherin 13
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHN1 chimerin 1
CNN3 calponin 3, acidic
CPA3 carboxypeptidase A3 (mast cell)
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL5 chemokine (C-X-C motif) ligand 5
CYTIP cytohesin 1 interacting protein
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFNA1 ephrin-A1
FAM13A family with sequence similarity 13, member A
FAM63A family with sequence similarity 63, member A
FBN2 fibrillin 2
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GNAS GNAS complex locus
GREM1 gremlin 1, DAN family BMP antagonist
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H2BG histone cluster 1, H2bg
HOXB2 homeobox B2
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGL immunoglobulin lambda locus
IRF9 interferon regulatory factor 9
ISYNA1 inositol-3-phosphate synthase 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
LGALS1 lectin, galactoside-binding, soluble, 1
LOXL2 lysyl oxidase-like 2
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
MBNL2 muscleblind-like splicing regulator 2
MDK midkine (neurite growth-promoting factor 2)
MMP10 matrix metallopeptidase 10
MMP12 matrix metallopeptidase 12
MTFR1 mitochondrial fission regulator 1
MTSS1 metastasis suppressor 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NPTX2 neuronal pentraxin II
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PRAME preferentially expressed antigen in melanoma
PTPRF protein tyrosine phosphatase, receptor type, F
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGCC regulator of cell cycle
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC38A1 solute carrier family 38, member 1
SNX13 sorting nexin 13
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STON1 stonin 1
SULF1 sulfatase 1
TBX3 T-box 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIMP3 TIMP metallopeptidase inhibitor 3
TOX3 TOX high mobility group box family member 3
TPD52 tumor protein D52
TRIM2 tripartite motif containing 2
VAV3 vav 3 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
ZBTB10 zinc finger and BTB domain containing 10
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AIM2 absent in melanoma 2
ASRGL1 asparaginase like 1
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
AURKA aurora kinase A
BTN3A2 butyrophilin, subfamily 3, member A2
CD47 CD47 molecule
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CP ceruloplasmin (ferroxidase)
CST7 cystatin F (leukocystatin)
CTR9 CTR9, Paf1/RNA polymerase II complex component
ECI2 enoyl-CoA delta isomerase 2
EIF4B eukaryotic translation initiation factor 4B
EPM2AIP1 EPM2A (laforin) interacting protein 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM46A family with sequence similarity 46, member A
FOS FBJ murine osteosarcoma viral oncogene homolog
GRWD1 glutamate-rich WD repeat containing 1
GYG1 glycogenin 1
HLTF helicase-like transcription factor
HOMER1 homer scaffolding protein 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KRT10 keratin 10, type I
MRPS30 mitochondrial ribosomal protein S30
NGRN neugrin, neurite outgrowth associated
NKG7 natural killer cell granule protein 7
NOTCH2 notch 2
ODC1 ornithine decarboxylase 1
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTP4A2 protein tyrosine phosphatase type IVA, member 2
REEP5 receptor accessory protein 5
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SACS sacsin molecular chaperone
SFN stratifin
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SOX4 SRY (sex determining region Y)-box 4
TUBB4B tubulin, beta 4B class IVb
UBE2S ubiquitin-conjugating enzyme E2S
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
WDTC1 WD and tetratricopeptide repeats 1
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
ZNF131 zinc finger protein 131