BRD-K83151319_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

86 genes differentially expressed following the BRD-K83151319_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AHCYL1 adenosylhomocysteinase-like 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANKRD10 ankyrin repeat domain 10
BASP1 brain abundant, membrane attached signal protein 1
C1S complement component 1, s subcomponent
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHI3L2 chitinase 3-like 2
CLU clusterin
COL3A1 collagen, type III, alpha 1
CTSL cathepsin L
CXCL13 chemokine (C-X-C motif) ligand 13
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELAVL1 ELAV like RNA binding protein 1
FTH1 ferritin, heavy polypeptide 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GRIA2 glutamate receptor, ionotropic, AMPA 2
HMOX1 heme oxygenase 1
HSPB8 heat shock 22kDa protein 8
IQCG IQ motif containing G
KEAP1 kelch-like ECH-associated protein 1
LY6D lymphocyte antigen 6 complex, locus D
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN2B1 mannosidase, alpha, class 2B, member 1
MAP1B microtubule-associated protein 1B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MUC4 mucin 4, cell surface associated
NAMPT nicotinamide phosphoribosyltransferase
PDLIM5 PDZ and LIM domain 5
PGD phosphogluconate dehydrogenase
PMP22 peripheral myelin protein 22
POPDC3 popeye domain containing 3
PRDX1 peroxiredoxin 1
RGS2 regulator of G-protein signaling 2
S100A7 S100 calcium binding protein A7
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TXNRD1 thioredoxin reductase 1
UBL3 ubiquitin-like 3
ZEB2 zinc finger E-box binding homeobox 2

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
ADGRG6 adhesion G protein-coupled receptor G6
ALB albumin
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
CCND2 cyclin D2
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CLIC5 chloride intracellular channel 5
CTGF connective tissue growth factor
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
F11R F11 receptor
FABP7 fatty acid binding protein 7, brain
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KRT18 keratin 18, type I
KRT8 keratin 8, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LPAR6 lysophosphatidic acid receptor 6
LXN latexin
LYZ lysozyme
MECOM MDS1 and EVI1 complex locus
PEG10 paternally expressed 10
PROM1 prominin 1
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGCC regulator of cell cycle
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SDC1 syndecan 1
SDC2 syndecan 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SST somatostatin
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TOP2A topoisomerase (DNA) II alpha 170kDa
TXNIP thioredoxin interacting protein
UGCG UDP-glucose ceramide glucosyltransferase
VAMP8 vesicle-associated membrane protein 8
WFDC1 WAP four-disulfide core domain 1
XIST X inactive specific transcript (non-protein coding)