BRD-K82928847_rocilinostat_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

56 genes differentially expressed following the BRD-K82928847_rocilinostat_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT1 acetyl-CoA acetyltransferase 1
ACTA2 actin, alpha 2, smooth muscle, aorta
ALCAM activated leukocyte cell adhesion molecule
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AQP1 aquaporin 1 (Colton blood group)
C6ORF62 chromosome 6 open reading frame 62
CD24 CD24 molecule
COCH cochlin
CTSC cathepsin C
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EFHD1 EF-hand domain family, member D1
FLRT3 fibronectin leucine rich transmembrane protein 3
IL13RA2 interleukin 13 receptor, alpha 2
KYNU kynureninase
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
MAP7 microtubule-associated protein 7
MYLK myosin light chain kinase
PLAT plasminogen activator, tissue
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRPH peripherin
RGS2 regulator of G-protein signaling 2
SFTPA2 surfactant protein A2
SFTPC surfactant protein C
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIMP3 TIMP metallopeptidase inhibitor 3
TKTL1 transketolase-like 1
TNNT1 troponin T type 1 (skeletal, slow)
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
ASS1 argininosuccinate synthase 1
BHLHE41 basic helix-loop-helix family, member e41
CCND2 cyclin D2
COPS7A COP9 signalosome subunit 7A
ENO2 enolase 2 (gamma, neuronal)
FXYD6 FXYD domain containing ion transport regulator 6
GTPBP8 GTP-binding protein 8 (putative)
HCAR3 hydroxycarboxylic acid receptor 3
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
LCN2 lipocalin 2
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LOX lysyl oxidase
LYZ lysozyme
OLFM4 olfactomedin 4
PCNA proliferating cell nuclear antigen
REG1A regenerating islet-derived 1 alpha
S100P S100 calcium binding protein P
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
TF transferrin
TFF1 trefoil factor 1
THBS4 thrombospondin 4
TIGAR TP53 induced glycolysis regulatory phosphatase
VTCN1 V-set domain containing T cell activation inhibitor 1