BRD-K82837433_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-K82837433_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
ADIRF adipogenesis regulatory factor
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C10ORF10 chromosome 10 open reading frame 10
CA2 carbonic anhydrase II
CA9 carbonic anhydrase IX
CCND2 cyclin D2
CD40 CD40 molecule, TNF receptor superfamily member 5
CFD complement factor D (adipsin)
CPE carboxypeptidase E
CTSS cathepsin S
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT4 DNA-damage-inducible transcript 4
DPYSL4 dihydropyrimidinase-like 4
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
DUSP3 dual specificity phosphatase 3
EGLN3 egl-9 family hypoxia-inducible factor 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ESRP1 epithelial splicing regulatory protein 1
F11R F11 receptor
FAM69A family with sequence similarity 69, member A
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GPNMB glycoprotein (transmembrane) nmb
GUSBP11 glucuronidase, beta pseudogene 11
HHEX hematopoietically expressed homeobox
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2BG histone cluster 1, H2bg
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLV2-23 immunoglobulin lambda variable 2-23
IPO13 importin 13
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
LDOC1 leucine zipper, down-regulated in cancer 1
LMO3 LIM domain only 3 (rhombotin-like 2)
MAOA monoamine oxidase A
MX1 MX dynamin-like GTPase 1
NLRP2 NLR family, pyrin domain containing 2
ORC1 origin recognition complex, subunit 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RAB20 RAB20, member RAS oncogene family
RAB25 RAB25, member RAS oncogene family
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE6 ribonuclease, RNase A family, k6
RSAD2 radical S-adenosyl methionine domain containing 2
RTN1 reticulon 1
SHB Src homology 2 domain containing adaptor protein B
SIRPA signal-regulatory protein alpha
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SNX10 sorting nexin 10
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SST somatostatin
ST18 suppression of tumorigenicity 18, zinc finger
STC1 stanniocalcin 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM30B transmembrane protein 30B
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNS1 tensin 1
TRIB3 tribbles pseudokinase 3
VEGFA vascular endothelial growth factor A
VNN1 vanin 1
VSIG4 V-set and immunoglobulin domain containing 4
XIST X inactive specific transcript (non-protein coding)
ZBTB16 zinc finger and BTB domain containing 16
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
AQP3 aquaporin 3 (Gill blood group)
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BAG2 BCL2-associated athanogene 2
BIN1 bridging integrator 1
CA12 carbonic anhydrase XII
CCL19 chemokine (C-C motif) ligand 19
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CHN1 chimerin 1
DEFB1 defensin, beta 1
EMP3 epithelial membrane protein 3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOLR1 folate receptor 1 (adult)
FZD7 frizzled class receptor 7
GAS1 growth arrest-specific 1
GRB14 growth factor receptor-bound protein 14
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
IGFBP4 insulin-like growth factor binding protein 4
KRT10 keratin 10, type I
LEF1 lymphoid enhancer-binding factor 1
LOXL1 lysyl oxidase-like 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MDFIC MyoD family inhibitor domain containing
MKNK2 MAP kinase interacting serine/threonine kinase 2
MTA1 metastasis associated 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP62 nucleoporin 62kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PRKCA protein kinase C, alpha
PRR7 proline rich 7 (synaptic)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
S100A2 S100 calcium binding protein A2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SNRPE small nuclear ribonucleoprotein polypeptide E
SPRR1A small proline-rich protein 1A
STXBP2 syntaxin binding protein 2
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TRIO trio Rho guanine nucleotide exchange factor
TUBB2B tubulin, beta 2B class IIb
UBE2S ubiquitin-conjugating enzyme E2S