BRD-K82823804_PD 407824_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

36 genes differentially expressed following the BRD-K82823804_PD 407824_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AREG amphiregulin
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
C6ORF62 chromosome 6 open reading frame 62
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CETN2 centrin, EF-hand protein, 2
CLIC4 chloride intracellular channel 4
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
GPRC5A G protein-coupled receptor, class C, group 5, member A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
INSIG1 insulin induced gene 1
KLF6 Kruppel-like factor 6
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MSMO1 methylsterol monooxygenase 1
PTX3 pentraxin 3, long
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQLE squalene epoxidase
TUBB6 tubulin, beta 6 class V

decreased expression

Symbol Name
BCL6 B-cell CLL/lymphoma 6
CDC25A cell division cycle 25A
CLTB clathrin, light chain B
HAT1 histone acetyltransferase 1
IRS2 insulin receptor substrate 2
LIG1 ligase I, DNA, ATP-dependent
NT5DC2 5'-nucleotidase domain containing 2
RFC2 replication factor C (activator 1) 2, 40kDa
RHOBTB3 Rho-related BTB domain containing 3
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SPINK1 serine peptidase inhibitor, Kazal type 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
VGLL4 vestigial-like family member 4