BRD-K82732294_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

231 genes differentially expressed following the BRD-K82732294_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
ARL8B ADP-ribosylation factor-like 8B
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AVPI1 arginine vasopressin-induced 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CBR3 carbonyl reductase 3
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CD163 CD163 molecule
CDA cytidine deaminase
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLCA2 chloride channel accessory 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CST1 cystatin SN
CTSL cathepsin L
CTSZ cathepsin Z
CXCL13 chemokine (C-X-C motif) ligand 13
CYB5R1 cytochrome b5 reductase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSC2 desmocollin 2
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
EMC3 ER membrane protein complex subunit 3
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPRS glutamyl-prolyl-tRNA synthetase
FAM134A family with sequence similarity 134, member A
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
FTL ferritin, light polypeptide
G6PD glucose-6-phosphate dehydrogenase
GABARAPL1 GABA(A) receptor-associated protein like 1
GARS glycyl-tRNA synthetase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GHITM growth hormone inducible transmembrane protein
GPX2 glutathione peroxidase 2
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IFRD1 interferon-related developmental regulator 1
IL1R2 interleukin 1 receptor, type II
KDM3A lysine (K)-specific demethylase 3A
KIF1B kinesin family member 1B
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLHL21 kelch-like family member 21
KPNA4 karyopherin alpha 4 (importin alpha 3)
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KYNU kynureninase
LRP10 low density lipoprotein receptor-related protein 10
LYPD3 LY6/PLAUR domain containing 3
MALL mal, T-cell differentiation protein-like
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MYO10 myosin X
NAMPT nicotinamide phosphoribosyltransferase
NFIL3 nuclear factor, interleukin 3 regulated
NPC1 Niemann-Pick disease, type C1
NUPR1 nuclear protein, transcriptional regulator, 1
PERP PERP, TP53 apoptosis effector
PGD phosphogluconate dehydrogenase
PI3 peptidase inhibitor 3, skin-derived
PIR pirin (iron-binding nuclear protein)
PKP1 plakophilin 1
PPAP2B phosphatidic acid phosphatase type 2B
PRSS3 protease, serine, 3
PSAP prosaposin
PSAT1 phosphoserine aminotransferase 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAB5A RAB5A, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RAP1GAP RAP1 GTPase activating protein
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SERINC1 serine incorporator 1
SERINC5 serine incorporator 5
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SETD5 SET domain containing 5
SFN stratifin
SH3BP4 SH3-domain binding protein 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SPRR1A small proline-rich protein 1A
SQSTM1 sequestosome 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STC2 stanniocalcin 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
TACC2 transforming, acidic coiled-coil containing protein 2
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TDO2 tryptophan 2,3-dioxygenase
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TRIB3 tribbles pseudokinase 3
TXNL1 thioredoxin-like 1
TXNRD1 thioredoxin reductase 1
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UPP1 uridine phosphorylase 1
ZFAND5 zinc finger, AN1-type domain 5
ZNF292 zinc finger protein 292
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDOB aldolase B, fructose-bisphosphate
ANXA9 annexin A9
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARMCX1 armadillo repeat containing, X-linked 1
ASCL1 achaete-scute family bHLH transcription factor 1
ASS1 argininosuccinate synthase 1
C7 complement component 7
CA9 carbonic anhydrase IX
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CFI complement factor I
CHRDL1 chordin-like 1
COMMD8 COMM domain containing 8
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DSCC1 DNA replication and sister chromatid cohesion 1
DUT deoxyuridine triphosphatase
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESR1 estrogen receptor 1
FABP1 fatty acid binding protein 1, liver
FBP1 fructose-1,6-bisphosphatase 1
FILIP1L filamin A interacting protein 1-like
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GRWD1 glutamate-rich WD repeat containing 1
GTPBP8 GTP-binding protein 8 (putative)
HADH hydroxyacyl-CoA dehydrogenase
HIST1H4C histone cluster 1, H4c
HLF hepatic leukemia factor
IFI16 interferon, gamma-inducible protein 16
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IL17RB interleukin 17 receptor B
ITGB1BP1 integrin beta 1 binding protein 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCTD12 potassium channel tetramerization domain containing 12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
METTL7A methyltransferase like 7A
MT1E metallothionein 1E
MUC1 mucin 1, cell surface associated
MXRA5 matrix-remodelling associated 5
MYB v-myb avian myeloblastosis viral oncogene homolog
NBN nibrin
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
NUP85 nucleoporin 85kDa
PAM peptidylglycine alpha-amidating monooxygenase
PDGFC platelet derived growth factor C
PEG10 paternally expressed 10
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLAT plasminogen activator, tissue
PLS1 plastin 1
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKD3 protein kinase D3
REG1A regenerating islet-derived 1 alpha
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPA3 replication protein A3, 14kDa
SALL2 spalt-like transcription factor 2
SAMD4A sterile alpha motif domain containing 4A
SCN3A sodium channel, voltage gated, type III alpha subunit
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SFRP1 secreted frizzled-related protein 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPDEF SAM pointed domain containing ETS transcription factor
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINK4 serine peptidase inhibitor, Kazal type 4
SPON1 spondin 1, extracellular matrix protein
SRSF6 serine/arginine-rich splicing factor 6
STS steroid sulfatase (microsomal), isozyme S
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TMSB15B thymosin beta 15B
TOB1 transducer of ERBB2, 1
TSPAN4 tetraspanin 4
TSPAN6 tetraspanin 6
TUSC3 tumor suppressor candidate 3
WT1 Wilms tumor 1
ZFPM2 zinc finger protein, FOG family member 2