BRD-K82732294_-666_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

183 genes differentially expressed following the BRD-K82732294_-666_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADRB2 adrenoceptor beta 2, surface
ANPEP alanyl (membrane) aminopeptidase
ANXA3 annexin A3
ARG2 arginase 2
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAG3 BCL2-associated athanogene 3
BAX BCL2-associated X protein
CACYBP calcyclin binding protein
CAPG capping protein (actin filament), gelsolin-like
CBS cystathionine-beta-synthase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CKS2 CDC28 protein kinase regulatory subunit 2
CLIC4 chloride intracellular channel 4
CNPY3 canopy FGF signaling regulator 3
CRYAB crystallin, alpha B
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
EPRS glutamyl-prolyl-tRNA synthetase
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GULP1 GULP, engulfment adaptor PTB domain containing 1
H1F0 H1 histone family, member 0
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
INHBA inhibin, beta A
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KLF6 Kruppel-like factor 6
LDLR low density lipoprotein receptor
LONP1 lon peptidase 1, mitochondrial
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MARS methionyl-tRNA synthetase
MBOAT7 membrane bound O-acyltransferase domain containing 7
MT1F metallothionein 1F
MT1M metallothionein 1M
NAMPT nicotinamide phosphoribosyltransferase
NFIL3 nuclear factor, interleukin 3 regulated
NNMT nicotinamide N-methyltransferase
NUPR1 nuclear protein, transcriptional regulator, 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PENK proenkephalin
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAP prosaposin
PXDN peroxidasin
RCAN1 regulator of calcineurin 1
RHOB ras homolog family member B
SARS seryl-tRNA synthetase
SCYL3 SCY1-like 3 (S. cerevisiae)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3YL1 SH3 and SYLF domain containing 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STK17B serine/threonine kinase 17b
TARS threonyl-tRNA synthetase
TPD52L2 tumor protein D52-like 2
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNL4B thioredoxin-like 4B
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ASPH aspartate beta-hydroxylase
BLCAP bladder cancer associated protein
C1QB complement component 1, q subcomponent, B chain
C3 complement component 3
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CCND1 cyclin D1
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLU clusterin
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
CP ceruloplasmin (ferroxidase)
CTSC cathepsin C
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
DACH1 dachshund family transcription factor 1
DCLK1 doublecortin-like kinase 1
DUSP4 dual specificity phosphatase 4
EGR2 early growth response 2
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ESR1 estrogen receptor 1
FASTKD5 FAST kinase domains 5
GBP1 guanylate binding protein 1, interferon-inducible
GCLC glutamate-cysteine ligase, catalytic subunit
GNAS GNAS complex locus
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGF1 insulin-like growth factor 1 (somatomedin C)
JADE2 jade family PHD finger 2
JAG1 jagged 1
KIAA0485 uncharacterized LOC57235
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRRC17 leucine rich repeat containing 17
LYPD1 LY6/PLAUR domain containing 1
LYZ lysozyme
MARCKS myristoylated alanine-rich protein kinase C substrate
MXRA5 matrix-remodelling associated 5
NCALD neurocalcin delta
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NOVA1 neuro-oncological ventral antigen 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NRN1 neuritin 1
OLFM1 olfactomedin 1
PALLD palladin, cytoskeletal associated protein
PSD3 pleckstrin and Sec7 domain containing 3
PTN pleiotrophin
RAB4A RAB4A, member RAS oncogene family
RNF167 ring finger protein 167
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
SEPP1 selenoprotein P, plasma, 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SPARCL1 SPARC-like 1 (hevin)
STAT1 signal transducer and activator of transcription 1, 91kDa
SUB1 SUB1 homolog (S. cerevisiae)
TCF4 transcription factor 4
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFRC transferrin receptor
TGM2 transglutaminase 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TM4SF1 transmembrane 4 L six family member 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UPK1B uroplakin 1B
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WEE1 WEE1 G2 checkpoint kinase
XIST X inactive specific transcript (non-protein coding)