BRD-K82731415_-666_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K82731415_-666_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANPEP alanyl (membrane) aminopeptidase
APOB apolipoprotein B
ARID5B AT rich interactive domain 5B (MRF1-like)
BEX4 brain expressed, X-linked 4
BTN3A2 butyrophilin, subfamily 3, member A2
C3 complement component 3
CALR calreticulin
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD9 CD9 molecule
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CLIC5 chloride intracellular channel 5
CPB1 carboxypeptidase B1 (tissue)
CPM carboxypeptidase M
CTSS cathepsin S
DHRS7 dehydrogenase/reductase (SDR family) member 7
DLK1 delta-like 1 homolog (Drosophila)
FGFR2 fibroblast growth factor receptor 2
FGL2 fibrinogen-like 2
FMO3 flavin containing monooxygenase 3
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSDMB gasdermin B
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXB2 homeobox B2
HOXB6 homeobox B6
IFI16 interferon, gamma-inducible protein 16
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IPO13 importin 13
IQGAP1 IQ motif containing GTPase activating protein 1
LEF1 lymphoid enhancer-binding factor 1
LY75 lymphocyte antigen 75
MEIS1 Meis homeobox 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NDRG2 NDRG family member 2
NMU neuromedin U
NPY1R neuropeptide Y receptor Y1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PRAME preferentially expressed antigen in melanoma
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RND3 Rho family GTPase 3
RTN1 reticulon 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SORBS2 sorbin and SH3 domain containing 2
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TLR4 toll-like receptor 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB2 tribbles pseudokinase 2
TRIM2 tripartite motif containing 2
TUSC3 tumor suppressor candidate 3
TXNL4B thioredoxin-like 4B
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WNT5A wingless-type MMTV integration site family, member 5A
WT1 Wilms tumor 1
XAF1 XIAP associated factor 1

decreased expression

Symbol Name
AGR2 anterior gradient 2
ALDOA aldolase A, fructose-bisphosphate
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
CD24 CD24 molecule
CDC42 cell division cycle 42
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CLIC4 chloride intracellular channel 4
COCH cochlin
COMP cartilage oligomeric matrix protein
CORO1A coronin, actin binding protein, 1A
CRIP1 cysteine-rich protein 1 (intestinal)
CRLF1 cytokine receptor-like factor 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EIF5A eukaryotic translation initiation factor 5A
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FBN2 fibrillin 2
GOLGA8H golgin A8 family, member H
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HN1 hematological and neurological expressed 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
LXN latexin
MAP7 microtubule-associated protein 7
MAT2A methionine adenosyltransferase II, alpha
MTCL1 microtubule crosslinking factor 1
PCOLCE2 procollagen C-endopeptidase enhancer 2
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
S100P S100 calcium binding protein P
SCRG1 stimulator of chondrogenesis 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
TESC tescalcin
THBS4 thrombospondin 4
TSPAN3 tetraspanin 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon