BRD-K82685933_BTB06091SC_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

134 genes differentially expressed following the BRD-K82685933_BTB06091SC_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AQP1 aquaporin 1 (Colton blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
BAG3 BCL2-associated athanogene 3
C9ORF91 chromosome 9 open reading frame 91
CD163 CD163 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD52 CD52 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
DCN decorin
DENND2D DENN/MADD domain containing 2D
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EDN3 endothelin 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FBP1 fructose-1,6-bisphosphatase 1
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
FXYD3 FXYD domain containing ion transport regulator 3
G6PD glucose-6-phosphate dehydrogenase
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
ITM2C integral membrane protein 2C
JCHAIN joining chain of multimeric IgA and IgM
KLF4 Kruppel-like factor 4 (gut)
KRT13 keratin 13, type I
MAN1A1 mannosidase, alpha, class 1A, member 1
MICB MHC class I polypeptide-related sequence B
MSLN mesothelin
MSX2 msh homeobox 2
MT1M metallothionein 1M
MUC5B mucin 5B, oligomeric mucus/gel-forming
NPTX2 neuronal pentraxin II
NQO1 NAD(P)H dehydrogenase, quinone 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PDGFA platelet-derived growth factor alpha polypeptide
PPAP2B phosphatidic acid phosphatase type 2B
PSAP prosaposin
PTX3 pentraxin 3, long
RAB21 RAB21, member RAS oncogene family
RND3 Rho family GTPase 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOWAHC sosondowah ankyrin repeat domain family member C
SQSTM1 sequestosome 1
TBX3 T-box 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM110 transmembrane protein 110
TMEM41B transmembrane protein 41B
TMSB15A thymosin beta 15a
TSC22D2 TSC22 domain family, member 2
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UBE2J1 ubiquitin-conjugating enzyme E2, J1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WNT5A wingless-type MMTV integration site family, member 5A
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADK adenosine kinase
AHNAK2 AHNAK nucleoprotein 2
AKAP12 A kinase (PRKA) anchor protein 12
ALDOA aldolase A, fructose-bisphosphate
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
BMI1 BMI1 proto-oncogene, polycomb ring finger
CCNA2 cyclin A2
CCND1 cyclin D1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
DCK deoxycytidine kinase
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
EREG epiregulin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FTO fat mass and obesity associated
GRB14 growth factor receptor-bound protein 14
HES1 hes family bHLH transcription factor 1
IFITM2 interferon induced transmembrane protein 2
IFRD2 interferon-related developmental regulator 2
IGFBP1 insulin-like growth factor binding protein 1
IGFBP6 insulin-like growth factor binding protein 6
KRT10 keratin 10, type I
LAMB1 laminin, beta 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTBP1 latent transforming growth factor beta binding protein 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NID2 nidogen 2 (osteonidogen)
OAT ornithine aminotransferase
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLK1 polo-like kinase 1
PLS3 plastin 3
PMM2 phosphomannomutase 2
PNMA2 paraneoplastic Ma antigen 2
POSTN periostin, osteoblast specific factor
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PUF60 poly-U binding splicing factor 60KDa
PXDN peroxidasin
RGS1 regulator of G-protein signaling 1
S100A10 S100 calcium binding protein A10
SORBS1 sorbin and SH3 domain containing 1
SULF1 sulfatase 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TNNC1 troponin C type 1 (slow)
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN3 tetraspanin 3
TUBB tubulin, beta class I