BRD-K82594686_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

61 genes differentially expressed following the BRD-K82594686_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5 arachidonate 5-lipoxygenase
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CA2 carbonic anhydrase II
CD200 CD200 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
DPP4 dipeptidyl-peptidase 4
ELANE elastase, neutrophil expressed
GNLY granulysin
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HBB hemoglobin, beta
HHEX hematopoietically expressed homeobox
KIAA1598
KLRB1 killer cell lectin-like receptor subfamily B, member 1
KRT18 keratin 18, type I
LITAF lipopolysaccharide-induced TNF factor
LOC100505650 uncharacterized LOC100505650
MNDA myeloid cell nuclear differentiation antigen
MYRF myelin regulatory factor
NNMT nicotinamide N-methyltransferase
PMM2 phosphomannomutase 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PTGER4 prostaglandin E receptor 4 (subtype EP4)
QPCT glutaminyl-peptide cyclotransferase
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RTN1 reticulon 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRGN serglycin
TARP TCR gamma alternate reading frame protein
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFA transforming growth factor, alpha
TGM2 transglutaminase 2
TMSB15A thymosin beta 15a
VAMP8 vesicle-associated membrane protein 8

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
BST2 bone marrow stromal cell antigen 2
CD59 CD59 molecule, complement regulatory protein
EFNB2 ephrin-B2
FABP7 fatty acid binding protein 7, brain
FOLR1 folate receptor 1 (adult)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GPM6B glycoprotein M6B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
LYPLA1 lysophospholipase I
MARCKS myristoylated alanine-rich protein kinase C substrate
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PFN2 profilin 2
PTN pleiotrophin
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
SCML1 sex comb on midleg-like 1 (Drosophila)
SEPP1 selenoprotein P, plasma, 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
THBS1 thrombospondin 1
TSPAN8 tetraspanin 8
TUBB2B tubulin, beta 2B class IIb
TWIST1 twist family bHLH transcription factor 1
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)