BRD-K82580504_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

144 genes differentially expressed following the BRD-K82580504_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANO1 anoctamin 1, calcium activated chloride channel
ANPEP alanyl (membrane) aminopeptidase
ASPN asporin
ATP2A3 ATPase, Ca++ transporting, ubiquitous
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C10ORF10 chromosome 10 open reading frame 10
CALML5 calmodulin-like 5
CD99 CD99 molecule
CDK6 cyclin-dependent kinase 6
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
DDIT4 DNA-damage-inducible transcript 4
EFNA1 ephrin-A1
EIF5A eukaryotic translation initiation factor 5A
ELANE elastase, neutrophil expressed
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP7 fatty acid binding protein 7, brain
FBN2 fibrillin 2
FKBP1B FK506 binding protein 1B, 12.6 kDa
FST follistatin
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GFOD1 glucose-fructose oxidoreductase domain containing 1
GUSBP11 glucuronidase, beta pseudogene 11
H1F0 H1 histone family, member 0
HHEX hematopoietically expressed homeobox
HSPA1A heat shock 70kDa protein 1A
HSPG2 heparan sulfate proteoglycan 2
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IL1R2 interleukin 1 receptor, type II
KDM5D lysine (K)-specific demethylase 5D
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
KRT7 keratin 7, type II
LBP lipopolysaccharide binding protein
LYN LYN proto-oncogene, Src family tyrosine kinase
MFAP5 microfibrillar associated protein 5
MMP7 matrix metallopeptidase 7
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
ORM1 orosomucoid 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PHGDH phosphoglycerate dehydrogenase
PLAU plasminogen activator, urokinase
PON3 paraoxonase 3
PPL periplakin
PTGIS prostaglandin I2 (prostacyclin) synthase
RGS5 regulator of G-protein signaling 5
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100P S100 calcium binding protein P
SFRP1 secreted frizzled-related protein 1
SOWAHC sosondowah ankyrin repeat domain family member C
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STEAP3 STEAP family member 3, metalloreductase
TACSTD2 tumor-associated calcium signal transducer 2
TGFA transforming growth factor, alpha
TGFBI transforming growth factor, beta-induced, 68kDa
TLK2 tousled-like kinase 2
TM4SF1 transmembrane 4 L six family member 1
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TRIB3 tribbles pseudokinase 3
TYROBP TYRO protein tyrosine kinase binding protein
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
ADD3 adducin 3 (gamma)
ADI1 acireductone dioxygenase 1
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARHGAP29 Rho GTPase activating protein 29
ARMT1 acidic residue methyltransferase 1
ATF1 activating transcription factor 1
ATG3 autophagy related 3
ATMIN ATM interactor
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BASP1 brain abundant, membrane attached signal protein 1
C6ORF62 chromosome 6 open reading frame 62
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CAV1 caveolin 1, caveolae protein, 22kDa
CBX1 chromobox homolog 1
CD52 CD52 molecule
CD83 CD83 molecule
CENPN centromere protein N
CHMP5 charged multivesicular body protein 5
CNN3 calponin 3, acidic
CREM cAMP responsive element modulator
DLD dihydrolipoamide dehydrogenase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
EDNRB endothelin receptor type B
EGR3 early growth response 3
EIF4B eukaryotic translation initiation factor 4B
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ENY2 enhancer of yellow 2 homolog (Drosophila)
G0S2 G0/G1 switch 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GCH1 GTP cyclohydrolase 1
HDGFRP3 hepatoma-derived growth factor, related protein 3
HEXIM1 hexamethylene bis-acetamide inducible 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
HRSP12 heat-responsive protein 12
INSIG1 insulin induced gene 1
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
LAPTM4B lysosomal protein transmembrane 4 beta
LDHB lactate dehydrogenase B
LUC7L3 LUC7-like 3 (S. cerevisiae)
LYPLA1 lysophospholipase I
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
OXR1 oxidation resistance 1
PGAM1 phosphoglycerate mutase 1 (brain)
PHLDA1 pleckstrin homology-like domain, family A, member 1
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PREPL prolyl endopeptidase-like
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRPF4 pre-mRNA processing factor 4
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAD23B RAD23 homolog B (S. cerevisiae)
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RPS11 ribosomal protein S11
S100A13 S100 calcium binding protein A13
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TFPI2 tissue factor pathway inhibitor 2
TMEM14B transmembrane protein 14B
TOP2A topoisomerase (DNA) II alpha 170kDa
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN31 tetraspanin 31
UBE3C ubiquitin protein ligase E3C
XPO7 exportin 7
YME1L1 YME1-like 1 ATPase
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta