BRD-K82384352_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

97 genes differentially expressed following the BRD-K82384352_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARL4C ADP-ribosylation factor-like 4C
BEX4 brain expressed, X-linked 4
CAST calpastatin
CD163 CD163 molecule
CD9 CD9 molecule
CFB complement factor B
CHRDL1 chordin-like 1
CLIC4 chloride intracellular channel 4
CPB1 carboxypeptidase B1 (tissue)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
FBLN1 fibulin 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FSD1 fibronectin type III and SPRY domain containing 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDO1 indoleamine 2,3-dioxygenase 1
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
KRT14 keratin 14, type I
KRT15 keratin 15, type I
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MDK midkine (neurite growth-promoting factor 2)
MSMO1 methylsterol monooxygenase 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPTX2 neuronal pentraxin II
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDZD2 PDZ domain containing 2
PERP PERP, TP53 apoptosis effector
PKP1 plakophilin 1
PRSS16 protease, serine, 16 (thymus)
PTN pleiotrophin
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RIN2 Ras and Rab interactor 2
RND3 Rho family GTPase 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SC5D sterol-C5-desaturase
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SFN stratifin
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SQLE squalene epoxidase
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TBX3 T-box 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM41B transmembrane protein 41B
TRAF5 TNF receptor-associated factor 5
TUBA1A tubulin, alpha 1a
TUSC3 tumor suppressor candidate 3
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDOB aldolase B, fructose-bisphosphate
CEMIP cell migration inducing protein, hyaluronan binding
COL3A1 collagen, type III, alpha 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMD dystrophin
EIF5B eukaryotic translation initiation factor 5B
EPHA3 EPH receptor A3
ERLIN1 ER lipid raft associated 1
FAM46A family with sequence similarity 46, member A
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
HOXC6 homeobox C6
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KNG1 kininogen 1
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MGP matrix Gla protein
MSH6 mutS homolog 6
NME4 NME/NM23 nucleoside diphosphate kinase 4
P4HB prolyl 4-hydroxylase, beta polypeptide
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PSPH phosphoserine phosphatase
PXMP2 peroxisomal membrane protein 2, 22kDa
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
STAT1 signal transducer and activator of transcription 1, 91kDa
TFF1 trefoil factor 1
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
ZMAT3 zinc finger, matrin-type 3