BRD-K82216340_medroxyprogesterone 17-acetate_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

76 genes differentially expressed following the BRD-K82216340_medroxyprogesterone 17-acetate_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
APOLD1 apolipoprotein L domain containing 1
CSTA cystatin A (stefin A)
CYB5A cytochrome b5 type A (microsomal)
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
EFHD1 EF-hand domain family, member D1
FAM107A family with sequence similarity 107, member A
FKBP5 FK506 binding protein 5
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IRS2 insulin receptor substrate 2
KLF2 Kruppel-like factor 2
KLF9 Kruppel-like factor 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PER1 period circadian clock 1
PRKCD protein kinase C, delta
RCAN2 regulator of calcineurin 2
RGS2 regulator of G-protein signaling 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VSIG4 V-set and immunoglobulin domain containing 4
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALOX5 arachidonate 5-lipoxygenase
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
ETV5 ets variant 5
FOSL1 FOS-like antigen 1
GBP2 guanylate binding protein 2, interferon-inducible
GMPR guanosine monophosphate reductase
GPR137B G protein-coupled receptor 137B
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
KIF14 kinesin family member 14
LY75 lymphocyte antigen 75
LYPD1 LY6/PLAUR domain containing 1
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
MATN2 matrilin 2
MID1 midline 1
MMP12 matrix metallopeptidase 12
NLGN4X neuroligin 4, X-linked
OLFM4 olfactomedin 4
PHLDA1 pleckstrin homology-like domain, family A, member 1
PRKCA protein kinase C, alpha
PTN pleiotrophin
RBP1 retinol binding protein 1, cellular
REG1B regenerating islet-derived 1 beta
RPL39L ribosomal protein L39-like
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SNCAIP synuclein, alpha interacting protein
TANK TRAF family member-associated NFKB activator
TGM2 transglutaminase 2
TRIB2 tribbles pseudokinase 2
ZBTB20 zinc finger and BTB domain containing 20