BRD-K82036761_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-K82036761_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACLY ATP citrate lyase
ADM adrenomedullin
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
AREG amphiregulin
ASS1 argininosuccinate synthase 1
BHLHE41 basic helix-loop-helix family, member e41
CTSA cathepsin A
CTSK cathepsin K
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
ELOVL6 ELOVL fatty acid elongase 6
FADS1 fatty acid desaturase 1
FBLN1 fibulin 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FGFR2 fibroblast growth factor receptor 2
FTH1 ferritin, heavy polypeptide 1
GAA glucosidase, alpha; acid
GRN granulin
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ICAM1 intercellular adhesion molecule 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF2R insulin-like growth factor 2 receptor
INSIG1 insulin induced gene 1
ITGB5 integrin, beta 5
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLF6 Kruppel-like factor 6
L1CAM L1 cell adhesion molecule
LDLR low density lipoprotein receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFAP5 microfibrillar associated protein 5
MSMO1 methylsterol monooxygenase 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
PERP PERP, TP53 apoptosis effector
PHLDA2 pleckstrin homology-like domain, family A, member 2
PSAP prosaposin
QPCT glutaminyl-peptide cyclotransferase
RAP1GAP RAP1 GTPase activating protein
RRAGD Ras-related GTP binding D
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SQLE squalene epoxidase
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TKT transketolase
TPP1 tripeptidyl peptidase I
TRIM16 tripartite motif containing 16
TRIM2 tripartite motif containing 2
TSKU tsukushi, small leucine rich proteoglycan
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EIF5 eukaryotic translation initiation factor 5
HMMR hyaluronan-mediated motility receptor (RHAMM)
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
MT1F metallothionein 1F
NCAPG non-SMC condensin I complex, subunit G
PLK1 polo-like kinase 1
PSRC1 proline/serine-rich coiled-coil 1
SPC25 SPC25, NDC80 kinetochore complex component
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
UBE2C ubiquitin-conjugating enzyme E2C
ZWINT ZW10 interacting kinetochore protein