BRD-K82036761_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

122 genes differentially expressed following the BRD-K82036761_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACOX2 acyl-CoA oxidase 2, branched chain
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHCYL1 adenosylhomocysteinase-like 1
AMACR alpha-methylacyl-CoA racemase
ANKRD10 ankyrin repeat domain 10
APOA1 apolipoprotein A-I
BASP1 brain abundant, membrane attached signal protein 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA1 carbonic anhydrase I
CAPG capping protein (actin filament), gelsolin-like
CFB complement factor B
CH25H cholesterol 25-hydroxylase
COL6A2 collagen, type VI, alpha 2
COX6C cytochrome c oxidase subunit VIc
CRABP2 cellular retinoic acid binding protein 2
DDIT4 DNA-damage-inducible transcript 4
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40
DPY19L4 dpy-19-like 4 (C. elegans)
EMX2 empty spiracles homeobox 2
EPHB2 EPH receptor B2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
FABP1 fatty acid binding protein 1, liver
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOXO3 forkhead box O3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GSN gelsolin
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
JUND jun D proto-oncogene
KIAA0226L KIAA0226-like
KIAA1598
LAMP1 lysosomal-associated membrane protein 1
LEF1 lymphoid enhancer-binding factor 1
MAP7 microtubule-associated protein 7
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MSMO1 methylsterol monooxygenase 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDZK1 PDZ domain containing 1
PIPOX pipecolic acid oxidase
PRSS8 protease, serine, 8
PXDN peroxidasin
RBKS ribokinase
SC5D sterol-C5-desaturase
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC2 syndecan 2
SERINC5 serine incorporator 5
SH3YL1 SH3 and SYLF domain containing 1
SIAH2 siah E3 ubiquitin protein ligase 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORBS3 sorbin and SH3 domain containing 3
SOX9 SRY (sex determining region Y)-box 9
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STC1 stanniocalcin 1
TMOD1 tropomodulin 1
TPBG trophoblast glycoprotein
UFM1 ubiquitin-fold modifier 1
WFS1 Wolfram syndrome 1 (wolframin)
ZFP36L2 ZFP36 ring finger protein-like 2
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALOX5 arachidonate 5-lipoxygenase
ANXA1 annexin A1
ANXA10 annexin A10
BMP4 bone morphogenetic protein 4
CD200 CD200 molecule
CD24 CD24 molecule
CTPS1 CTP synthase 1
CTSS cathepsin S
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
DLD dihydrolipoamide dehydrogenase
DUSP6 dual specificity phosphatase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASTKD5 FAST kinase domains 5
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
KRT14 keratin 14, type I
LDHB lactate dehydrogenase B
LYZ lysozyme
MACF1 microtubule-actin crosslinking factor 1
MIA melanoma inhibitory activity
MTCL1 microtubule crosslinking factor 1
NCK1 NCK adaptor protein 1
NFIB nuclear factor I/B
ODC1 ornithine decarboxylase 1
PDLIM1 PDZ and LIM domain 1
PEG3 paternally expressed 3
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI2 tissue factor pathway inhibitor 2
TM4SF1 transmembrane 4 L six family member 1
TRAPPC3 trafficking protein particle complex 3
TSPAN13 tetraspanin 13
TSPO translocator protein (18kDa)
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
XIST X inactive specific transcript (non-protein coding)