BRD-K81814927_-666_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

221 genes differentially expressed following the BRD-K81814927_-666_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALB albumin
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
APOB apolipoprotein B
APOLD1 apolipoprotein L domain containing 1
AQP1 aquaporin 1 (Colton blood group)
AQP9 aquaporin 9
ATF3 activating transcription factor 3
BEX1 brain expressed, X-linked 1
CADM1 cell adhesion molecule 1
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CD52 CD52 molecule
CEP70 centrosomal protein 70kDa
CES1 carboxylesterase 1
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COLEC12 collectin sub-family member 12
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CPM carboxypeptidase M
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DKK3 dickkopf WNT signaling pathway inhibitor 3
DSP desmoplakin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
FBLN1 fibulin 1
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FRY furry homolog (Drosophila)
GADD45B growth arrest and DNA-damage-inducible, beta
GAGE3 G antigen 3
GAS6 growth arrest-specific 6
GPNMB glycoprotein (transmembrane) nmb
GRIA2 glutamate receptor, ionotropic, AMPA 2
HBE1 hemoglobin, epsilon 1
HMGN4 high mobility group nucleosomal binding domain 4
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
IL7R interleukin 7 receptor
ISYNA1 inositol-3-phosphate synthase 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0226L KIAA0226-like
LEF1 lymphoid enhancer-binding factor 1
LRRC17 leucine rich repeat containing 17
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
METTL7A methyltransferase like 7A
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MN1 meningioma (disrupted in balanced translocation) 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1M metallothionein 1M
MXI1 MAX interactor 1, dimerization protein
NTS neurotensin
ORM1 orosomucoid 1
PBX3 pre-B-cell leukemia homeobox 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLVAP plasmalemma vesicle associated protein
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
RTN1 reticulon 1
SCARB2 scavenger receptor class B, member 2
SDC2 syndecan 2
SDC3 syndecan 3
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SPARCL1 SPARC-like 1 (hevin)
STC1 stanniocalcin 1
SULF1 sulfatase 1
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TRD T cell receptor delta locus
TRIM2 tripartite motif containing 2
TSPAN7 tetraspanin 7
TUSC3 tumor suppressor candidate 3
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACBD3 acyl-CoA binding domain containing 3
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AHNAK AHNAK nucleoprotein
AMD1 adenosylmethionine decarboxylase 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARMCX6 armadillo repeat containing, X-linked 6
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
C14ORF166 chromosome 14 open reading frame 166
CALML5 calmodulin-like 5
CANT1 calcium activated nucleotidase 1
CBR3 carbonyl reductase 3
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDCA4 cell division cycle associated 4
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CGRRF1 cell growth regulator with ring finger domain 1
CLTC clathrin, heavy chain (Hc)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EIF5 eukaryotic translation initiation factor 5
FA2H fatty acid 2-hydroxylase
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GMDS GDP-mannose 4,6-dehydratase
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GTPBP8 GTP-binding protein 8 (putative)
H2AFX H2A histone family, member X
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP4 insulin-like growth factor binding protein 4
JMJD6 jumonji domain containing 6
KDM2A lysine (K)-specific demethylase 2A
KIF2C kinesin family member 2C
KLK11 kallikrein-related peptidase 11
KRT10 keratin 10, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
KRT81 keratin 81, type II
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARCKSL1 MARCKS-like 1
MGLL monoglyceride lipase
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLPH melanophilin
MTERF3 mitochondrial transcription termination factor 3
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYBPC1 myosin binding protein C, slow type
NFIB nuclear factor I/B
NKX3-1 NK3 homeobox 1
NOP56 NOP56 ribonucleoprotein
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PI3 peptidase inhibitor 3, skin-derived
PKM pyruvate kinase, muscle
PKP1 plakophilin 1
PLA2G16 phospholipase A2, group XVI
PNP purine nucleoside phosphorylase
PROM1 prominin 1
PRPF19 pre-mRNA processing factor 19
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
RAE1 ribonucleic acid export 1
RGS2 regulator of G-protein signaling 2
RIN2 Ras and Rab interactor 2
RNMT RNA (guanine-7-) methyltransferase
RNPS1 RNA binding protein S1, serine-rich domain
RPL36AL ribosomal protein L36a-like
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRAGC Ras-related GTP binding C
RREB1 ras responsive element binding protein 1
S100A6 S100 calcium binding protein A6
S100A7 S100 calcium binding protein A7
SCEL sciellin
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC35F2 solute carrier family 35, member F2
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPDEF SAM pointed domain containing ETS transcription factor
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D8 TBC1 domain family, member 8 (with GRAM domain)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMEM11 transmembrane protein 11
TMX4 thioredoxin-related transmembrane protein 4
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNPO1 transportin 1
TRAPPC3 trafficking protein particle complex 3
TRIP10 thyroid hormone receptor interactor 10
TSPAN8 tetraspanin 8
TSPYL5 TSPY-like 5
TXLNA taxilin alpha
TYMS thymidylate synthetase
U2AF1 U2 small nuclear RNA auxiliary factor 1
USP22 ubiquitin specific peptidase 22
VGLL4 vestigial-like family member 4
ZFP36L1 ZFP36 ring finger protein-like 1
ZMYM2 zinc finger, MYM-type 2
ZNF185 zinc finger protein 185 (LIM domain)