BRD-K81814927_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

324 genes differentially expressed following the BRD-K81814927_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRF5 adhesion G protein-coupled receptor F5
AIDA axin interactor, dorsalization associated
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANOS1 anosmin 1
ARL4C ADP-ribosylation factor-like 4C
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BSG basigin (Ok blood group)
CALD1 caldesmon 1
CAV2 caveolin 2
CCL20 chemokine (C-C motif) ligand 20
CD36 CD36 molecule (thrombospondin receptor)
CD59 CD59 molecule, complement regulatory protein
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CFB complement factor B
CHGB chromogranin B
CLC Charcot-Leyden crystal galectin
CLIC5 chloride intracellular channel 5
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CP ceruloplasmin (ferroxidase)
CPM carboxypeptidase M
CTSZ cathepsin Z
CYB5A cytochrome b5 type A (microsomal)
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DHCR24 24-dehydrocholesterol reductase
DOK5 docking protein 5
DPP4 dipeptidyl-peptidase 4
DPYD dihydropyrimidine dehydrogenase
DPYSL3 dihydropyrimidinase-like 3
EMP1 epithelial membrane protein 1
EPAS1 endothelial PAS domain protein 1
FBN2 fibrillin 2
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGFR2 fibroblast growth factor receptor 2
FLOT1 flotillin 1
FLT1 fms-related tyrosine kinase 1
FST follistatin
FSTL1 follistatin-like 1
GAS6 growth arrest-specific 6
GPC4 glypican 4
GPM6A glycoprotein M6A
GSTA1 glutathione S-transferase alpha 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXB2 homeobox B2
IDO1 indoleamine 2,3-dioxygenase 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM3 interferon induced transmembrane protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL7R interleukin 7 receptor
INA internexin neuronal intermediate filament protein, alpha
INSM1 insulinoma-associated 1
ISG15 ISG15 ubiquitin-like modifier
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNK3 potassium channel, two pore domain subfamily K, member 3
KDR kinase insert domain receptor
LAMP3 lysosomal-associated membrane protein 3
MAOA monoamine oxidase A
MAP1B microtubule-associated protein 1B
MDFIC MyoD family inhibitor domain containing
MLF1 myeloid leukemia factor 1
MMP10 matrix metallopeptidase 10
MSN moesin
MUT methylmalonyl CoA mutase
NDFIP1 Nedd4 family interacting protein 1
NEFH neurofilament, heavy polypeptide
NMU neuromedin U
NPTX2 neuronal pentraxin II
NQO2 NAD(P)H dehydrogenase, quinone 2
NTS neurotensin
P3H2 prolyl 3-hydroxylase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK6 proprotein convertase subtilisin/kexin type 6
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG10 paternally expressed 10
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PSPH phosphoserine phosphatase
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEPT10 septin 10
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SOX11 SRY (sex determining region Y)-box 11
SST somatostatin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STEAP1 six transmembrane epithelial antigen of the prostate 1
STS steroid sulfatase (microsomal), isozyme S
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TPM2 tropomyosin 2 (beta)
TRDV3 T cell receptor delta variable 3
TSPAN12 tetraspanin 12
UGP2 UDP-glucose pyrophosphorylase 2
VIM vimentin
VTCN1 V-set domain containing T cell activation inhibitor 1

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACBD3 acyl-CoA binding domain containing 3
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AFF1 AF4/FMR2 family, member 1
AGR2 anterior gradient 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4A ADP-ribosylation factor-like 4A
ASF1A anti-silencing function 1A histone chaperone
AURKA aurora kinase A
AXIN1 axin 1
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BAMBI BMP and activin membrane-bound inhibitor
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BLCAP bladder cancer associated protein
BLM Bloom syndrome, RecQ helicase-like
BRPF1 bromodomain and PHD finger containing, 1
C14ORF169 chromosome 14 open reading frame 169
C6ORF48 chromosome 6 open reading frame 48
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNF cyclin F
CD58 CD58 molecule
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CENPA centromere protein A
CEP350 centrosomal protein 350kDa
CEP76 centrosomal protein 76kDa
CGRRF1 cell growth regulator with ring finger domain 1
CHD1 chromodomain helicase DNA binding protein 1
CHERP calcium homeostasis endoplasmic reticulum protein
CHPT1 choline phosphotransferase 1
CHSY1 chondroitin sulfate synthase 1
CLK4 CDC-like kinase 4
CLP1 cleavage and polyadenylation factor I subunit 1
CNOT4 CCR4-NOT transcription complex, subunit 4
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRTC3 CREB regulated transcription coactivator 3
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DCLRE1C DNA cross-link repair 1C
DDIT4 DNA-damage-inducible transcript 4
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKFZP586I1420 uncharacterized protein DKFZp586I1420
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DPF2 D4, zinc and double PHD fingers family 2
EIF4B eukaryotic translation initiation factor 4B
EIF5 eukaryotic translation initiation factor 5
ELF1 E74-like factor 1 (ets domain transcription factor)
EXOSC4 exosome component 4
FADD Fas (TNFRSF6)-associated via death domain
FAM208B family with sequence similarity 208, member B
FEM1B fem-1 homolog b (C. elegans)
FNBP4 formin binding protein 4
FOXO3 forkhead box O3
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
FZD7 frizzled class receptor 7
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA2 GATA binding protein 2
GATA3 GATA binding protein 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GEMIN4 gem (nuclear organelle) associated protein 4
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HOMER1 homer scaffolding protein 1
HOXA5 homeobox A5
HOXC6 homeobox C6
HSPA14 heat shock 70kDa protein 14
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IER5 immediate early response 5
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ING1 inhibitor of growth family, member 1
INTS6 integrator complex subunit 6
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JADE2 jade family PHD finger 2
JARID2 jumonji, AT rich interactive domain 2
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KDM2A lysine (K)-specific demethylase 2A
KIAA0485 uncharacterized LOC57235
KIAA0907 KIAA0907
KIN Kin17 DNA and RNA binding protein
KIZ kizuna centrosomal protein
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT7 keratin 7, type II
KYNU kynureninase
LIPT1 lipoyltransferase 1
LPIN1 lipin 1
LRIF1 ligand dependent nuclear receptor interacting factor 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2A methionine adenosyltransferase II, alpha
MCM10 minichromosome maintenance complex component 10
MED13 mediator complex subunit 13
MED17 mediator complex subunit 17
METTL18 methyltransferase like 18
MGP matrix Gla protein
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MSX2 msh homeobox 2
MTF2 metal response element binding transcription factor 2
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGDN neuroguidin, EIF4E binding protein
NOTCH2 notch 2
NOTCH2NL notch 2 N-terminal like
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
OSR2 odd-skipped related transciption factor 2
PARP2 poly (ADP-ribose) polymerase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PCF11 PCF11 cleavage and polyadenylation factor subunit
PDGFA platelet-derived growth factor alpha polypeptide
PDS5B PDS5 cohesin associated factor B
PER2 period circadian clock 2
PEX11A peroxisomal biogenesis factor 11 alpha
PFKP phosphofructokinase, platelet
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
PMEPA1 prostate transmembrane protein, androgen induced 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGES prostaglandin E synthase
PURA purine-rich element binding protein A
RAD9A RAD9 homolog A (S. pombe)
RBM15 RNA binding motif protein 15
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RHOB ras homolog family member B
RHOBTB3 Rho-related BTB domain containing 3
RNF111 ring finger protein 111
RNF113A ring finger protein 113A
RNMT RNA (guanine-7-) methyltransferase
RPP38 ribonuclease P/MRP 38kDa subunit
RPS11 ribosomal protein S11
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SACS sacsin molecular chaperone
SAP30 Sin3A-associated protein, 30kDa
SCAF8 SR-related CTD-associated factor 8
SESN1 sestrin 1
SETD1B SET domain containing 1B
SETD5 SET domain containing 5
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A44 solute carrier family 25, member 44
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRSF7 serine/arginine-rich splicing factor 7
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBK1 TANK-binding kinase 1
TBP TATA box binding protein
TBPL1 TBP-like 1
TBX2 T-box 2
TBX3 T-box 3
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF1 trefoil factor 1
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
TGS1 trimethylguanosine synthase 1
THAP11 THAP domain containing 11
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLK2 tousled-like kinase 2
TMEM243 transmembrane protein 243, mitochondrial
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNPO1 transportin 1
TOB1 transducer of ERBB2, 1
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TSPYL5 TSPY-like 5
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
USP1 ubiquitin specific peptidase 1
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
WAC WW domain containing adaptor with coiled-coil
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBED5 zinc finger, BED-type containing 5
ZBTB11 zinc finger and BTB domain containing 11
ZBTB38 zinc finger and BTB domain containing 38
ZC3H4 zinc finger CCCH-type containing 4
ZCCHC8 zinc finger, CCHC domain containing 8
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF107 zinc finger protein 107
ZNF131 zinc finger protein 131
ZNF200 zinc finger protein 200
ZNF217 zinc finger protein 217
ZNF22 zinc finger protein 22
ZNF232 zinc finger protein 232
ZNF267 zinc finger protein 267
ZNF443 zinc finger protein 443
ZNF7 zinc finger protein 7