BRD-K81814927_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

145 genes differentially expressed following the BRD-K81814927_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACP5 acid phosphatase 5, tartrate resistant
APP amyloid beta (A4) precursor protein
ARG2 arginase 2
ASPN asporin
C10ORF10 chromosome 10 open reading frame 10
CA2 carbonic anhydrase II
CCR2 chemokine (C-C motif) receptor 2
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CLEC4A C-type lectin domain family 4, member A
CPE carboxypeptidase E
DENND1B DENN/MADD domain containing 1B
DKK3 dickkopf WNT signaling pathway inhibitor 3
EXT1 exostosin glycosyltransferase 1
FAM69A family with sequence similarity 69, member A
FLT1 fms-related tyrosine kinase 1
FOS FBJ murine osteosarcoma viral oncogene homolog
GJA1 gap junction protein, alpha 1, 43kDa
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GRB7 growth factor receptor-bound protein 7
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HIST1H4C histone cluster 1, H4c
HLA-B major histocompatibility complex, class I, B
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IER3 immediate early response 3
IL17RB interleukin 17 receptor B
ISG15 ISG15 ubiquitin-like modifier
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITM2C integral membrane protein 2C
KIAA0930 KIAA0930
KIAA1462 KIAA1462
LAMP3 lysosomal-associated membrane protein 3
LMO3 LIM domain only 3 (rhombotin-like 2)
LPAR6 lysophosphatidic acid receptor 6
LTB lymphotoxin beta (TNF superfamily, member 3)
MAOA monoamine oxidase A
MFAP2 microfibrillar-associated protein 2
MMP9 matrix metallopeptidase 9
NDRG1 N-myc downstream regulated 1
NPTX2 neuronal pentraxin II
P3H2 prolyl 3-hydroxylase 2
PDE4A phosphodiesterase 4A, cAMP-specific
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PMM2 phosphomannomutase 2
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSPH phosphoserine phosphatase
PTPRE protein tyrosine phosphatase, receptor type, E
PYCARD PYD and CARD domain containing
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RFTN1 raftlin, lipid raft linker 1
RGS10 regulator of G-protein signaling 10
SDC1 syndecan 1
SDC2 syndecan 2
SHB Src homology 2 domain containing adaptor protein B
SIRPA signal-regulatory protein alpha
SNX10 sorting nexin 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPON2 spondin 2, extracellular matrix protein
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TGFA transforming growth factor, alpha
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176B transmembrane protein 176B
TNNT1 troponin T type 1 (skeletal, slow)
TUBA1A tubulin, alpha 1a
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGR2 anterior gradient 2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
APOD apolipoprotein D
AURKA aurora kinase A
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DCLK1 doublecortin-like kinase 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EAPP E2F-associated phosphoprotein
FAM46A family with sequence similarity 46, member A
FMO2 flavin containing monooxygenase 2 (non-functional)
FZD7 frizzled class receptor 7
GATA3 GATA binding protein 3
HBB hemoglobin, beta
HMOX1 heme oxygenase 1
IGFBP4 insulin-like growth factor binding protein 4
JMJD6 jumonji domain containing 6
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT7 keratin 7, type II
LMNA lamin A/C
MAL mal, T-cell differentiation protein
MARCKS myristoylated alanine-rich protein kinase C substrate
MFSD10 major facilitator superfamily domain containing 10
MSH6 mutS homolog 6
MYC v-myc avian myelocytomatosis viral oncogene homolog
NID2 nidogen 2 (osteonidogen)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
PCNA proliferating cell nuclear antigen
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKP phosphofructokinase, platelet
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PNN pinin, desmosome associated protein
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM15 RNA binding motif protein 15
RCAN1 regulator of calcineurin 1
RGS2 regulator of G-protein signaling 2
RPL27A ribosomal protein L27a
RPP38 ribonuclease P/MRP 38kDa subunit
RPS11 ribosomal protein S11
SACS sacsin molecular chaperone
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SORBS1 sorbin and SH3 domain containing 1
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMP4 TIMP metallopeptidase inhibitor 4
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
UPK1B uroplakin 1B
USP1 ubiquitin specific peptidase 1
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBTB38 zinc finger and BTB domain containing 38