BRD-K81814927_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

174 genes differentially expressed following the BRD-K81814927_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRF5 adhesion G protein-coupled receptor F5
ADIRF adipogenesis regulatory factor
AEBP1 AE binding protein 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA4 annexin A4
ANXA9 annexin A9
ATF3 activating transcription factor 3
BTG2 BTG family, member 2
CCND2 cyclin D2
CD52 CD52 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL4A5 collagen, type IV, alpha 5
CPE carboxypeptidase E
CPM carboxypeptidase M
CTSK cathepsin K
CXCR4 chemokine (C-X-C motif) receptor 4
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCN decorin
DKK3 dickkopf WNT signaling pathway inhibitor 3
EFHD1 EF-hand domain family, member D1
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPAS1 endothelial PAS domain protein 1
ESRP1 epithelial splicing regulatory protein 1
EXPH5 exophilin 5
F11R F11 receptor
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR3 fibroblast growth factor receptor 3
FILIP1L filamin A interacting protein 1-like
FRY furry homolog (Drosophila)
GLT8D2 glycosyltransferase 8 domain containing 2
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IRF6 interferon regulatory factor 6
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA1598
LGALS3 lectin, galactoside-binding, soluble, 3
LPAR6 lysophosphatidic acid receptor 6
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOB monoamine oxidase B
MDFIC MyoD family inhibitor domain containing
MEF2C myocyte enhancer factor 2C
MPZL2 myelin protein zero-like 2
OLFM4 olfactomedin 4
PBX3 pre-B-cell leukemia homeobox 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PECAM1 platelet/endothelial cell adhesion molecule 1
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha
PON3 paraoxonase 3
PRKCI protein kinase C, iota
PRSS16 protease, serine, 16 (thymus)
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCAN2 regulator of calcineurin 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPT2 septin 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SOX17 SRY (sex determining region Y)-box 17
SPTSSA serine palmitoyltransferase, small subunit A
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TMEM35 transmembrane protein 35
TMSB15A thymosin beta 15a
UGP2 UDP-glucose pyrophosphorylase 2
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC1 WAP four-disulfide core domain 1
WLS wntless Wnt ligand secretion mediator
ZNF117 zinc finger protein 117

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARFIP2 ADP-ribosylation factor interacting protein 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
CCNA2 cyclin A2
CCNF cyclin F
CD59 CD59 molecule, complement regulatory protein
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHPT1 choline phosphotransferase 1
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTTN cortactin
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYTL1 cytokine-like 1
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
DYNLL1 dynein, light chain, LC8-type 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EXOSC4 exosome component 4
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOSL1 FOS-like antigen 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRWD1 glutamate-rich WD repeat containing 1
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IGFBP4 insulin-like growth factor binding protein 4
IL1R2 interleukin 1 receptor, type II
JADE1 jade family PHD finger 1
JMJD6 jumonji domain containing 6
KRT10 keratin 10, type I
MARCKSL1 MARCKS-like 1
MCL1 myeloid cell leukemia 1
MIA melanoma inhibitory activity
MUC5B mucin 5B, oligomeric mucus/gel-forming
NET1 neuroepithelial cell transforming 1
NUP62 nucleoporin 62kDa
PFKP phosphofructokinase, platelet
PPIF peptidylprolyl isomerase F
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RBM14 RNA binding motif protein 14
RBM34 RNA binding motif protein 34
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPL27A ribosomal protein L27a
RPL36 ribosomal protein L36
RPL36AL ribosomal protein L36a-like
RPL37A ribosomal protein L37a
RPP25 ribonuclease P/MRP 25kDa subunit
RPS11 ribosomal protein S11
RPS26 ribosomal protein S26
RPS27L ribosomal protein S27-like
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX3 runt-related transcription factor 3
S100A2 S100 calcium binding protein A2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC35F2 solute carrier family 35, member F2
SLIRP SRA stem-loop interacting RNA binding protein
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SQSTM1 sequestosome 1
SRGN serglycin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TNPO1 transportin 1
TRAPPC3 trafficking protein particle complex 3
TXLNA taxilin alpha
TXNDC9 thioredoxin domain containing 9
UBE2S ubiquitin-conjugating enzyme E2S