BRD-K81795824_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

113 genes differentially expressed following the BRD-K81795824_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AEBP1 AE binding protein 1
AK4 adenylate kinase 4
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ASPN asporin
ATF3 activating transcription factor 3
BAX BCL2-associated X protein
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA9 carbonic anhydrase IX
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CSRP2 cysteine and glycine-rich protein 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DUSP1 dual specificity phosphatase 1
EGLN3 egl-9 family hypoxia-inducible factor 3
ENO2 enolase 2 (gamma, neuronal)
FABP7 fatty acid binding protein 7, brain
FAM57A family with sequence similarity 57, member A
FKBP10 FK506 binding protein 10, 65 kDa
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GADD45B growth arrest and DNA-damage-inducible, beta
GOLGA8A golgin A8 family, member A
GPI glucose-6-phosphate isomerase
HCAR3 hydroxycarboxylic acid receptor 3
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HLA-B major histocompatibility complex, class I, B
IER3 immediate early response 3
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IGFBP3 insulin-like growth factor binding protein 3
IL1R2 interleukin 1 receptor, type II
INSIG2 insulin induced gene 2
KDM3A lysine (K)-specific demethylase 3A
KDM4B lysine (K)-specific demethylase 4B
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
LGALS8 lectin, galactoside-binding, soluble, 8
LOXL1 lysyl oxidase-like 1
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAPT microtubule-associated protein tau
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MUC5B mucin 5B, oligomeric mucus/gel-forming
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAUR plasminogen activator, urokinase receptor
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
PNMA2 paraneoplastic Ma antigen 2
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
RGCC regulator of cell cycle
RNMT RNA (guanine-7-) methyltransferase
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A7 S100 calcium binding protein A7
SERTAD2 SERTA domain containing 2
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPAG4 sperm associated antigen 4
STC2 stanniocalcin 2
TFRC transferrin receptor
TGFA transforming growth factor, alpha
TMEM45A transmembrane protein 45A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor

decreased expression

Symbol Name
ACPP acid phosphatase, prostate
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
CCNF cyclin F
CDC25B cell division cycle 25B
CDCA8 cell division cycle associated 8
CEP55 centrosomal protein 55kDa
COL3A1 collagen, type III, alpha 1
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
MDFIC MyoD family inhibitor domain containing
MXRA7 matrix-remodelling associated 7
NPY neuropeptide Y
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLK1 polo-like kinase 1
PTTG1 pituitary tumor-transforming 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN12 tetraspanin 12
UBE2C ubiquitin-conjugating enzyme E2C