BRD-K81795824_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

331 genes differentially expressed following the BRD-K81795824_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
ALDOA aldolase A, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ANXA1 annexin A1
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BHLHE40 basic helix-loop-helix family, member e40
BMP7 bone morphogenetic protein 7
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CA9 carbonic anhydrase IX
CADM1 cell adhesion molecule 1
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
CLNS1A chloride channel, nucleotide-sensitive, 1A
COMP cartilage oligomeric matrix protein
CTSB cathepsin B
CXCL8 chemokine (C-X-C motif) ligand 8
DARS aspartyl-tRNA synthetase
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EGLN3 egl-9 family hypoxia-inducible factor 3
ELL2 elongation factor, RNA polymerase II, 2
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
ERO1L ERO1-like (S. cerevisiae)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM129A family with sequence similarity 129, member A
FAM162A family with sequence similarity 162, member A
FN1 fibronectin 1
FNDC3B fibronectin type III domain containing 3B
FZD5 frizzled class receptor 5
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GBE1 glucan (1,4-alpha-), branching enzyme 1
GCLC glutamate-cysteine ligase, catalytic subunit
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GOLGA8B golgin A8 family, member B
GPR87 G protein-coupled receptor 87
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX2 glutathione peroxidase 2
GTPBP2 GTP binding protein 2
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HLA-B major histocompatibility complex, class I, B
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IGFBP3 insulin-like growth factor binding protein 3
IL32 interleukin 32
INHBA inhibin, beta A
INSIG2 insulin induced gene 2
ISG20 interferon stimulated exonuclease gene 20kDa
JAG1 jagged 1
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM7A lysine (K)-specific demethylase 7A
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT17 keratin 17, type I
KRT23 keratin 23, type I
KRT6A keratin 6A, type II
KRT7 keratin 7, type II
LAMB3 laminin, beta 3
LARP6 La ribonucleoprotein domain family, member 6
LITAF lipopolysaccharide-induced TNF factor
LOX lysyl oxidase
LOXL2 lysyl oxidase-like 2
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MXI1 MAX interactor 1, dimerization protein
NCF2 neutrophil cytosolic factor 2
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NRN1 neuritin 1
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PERP PERP, TP53 apoptosis effector
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PHLDA3 pleckstrin homology-like domain, family A, member 3
PLIN2 perilipin 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
POPDC3 popeye domain containing 3
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PSAT1 phosphoserine aminotransferase 1
RB1CC1 RB1-inducible coiled-coil 1
RIOK3 RIO kinase 3
RNASET2 ribonuclease T2
RND3 Rho family GTPase 3
S100A4 S100 calcium binding protein A4
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCARB1 scavenger receptor class B, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERINC5 serine incorporator 5
SERTAD2 SERTA domain containing 2
SESN1 sestrin 1
SH3YL1 SH3 and SYLF domain containing 1
SIK1 salt-inducible kinase 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPAG4 sperm associated antigen 4
STC1 stanniocalcin 1
STC2 stanniocalcin 2
SULF1 sulfatase 1
TFRC transferrin receptor
TGFA transforming growth factor, alpha
TGIF1 TGFB-induced factor homeobox 1
TIGAR TP53 induced glycolysis regulatory phosphatase
TIMP3 TIMP metallopeptidase inhibitor 3
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMEM45A transmembrane protein 45A
TMPRSS4 transmembrane protease, serine 4
TNIP1 TNFAIP3 interacting protein 1
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZFAND5 zinc finger, AN1-type domain 5
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGR2 anterior gradient 2
AMDHD2 amidohydrolase domain containing 2
AQP1 aquaporin 1 (Colton blood group)
ARF6 ADP-ribosylation factor 6
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BCHE butyrylcholinesterase
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C20ORF27 chromosome 20 open reading frame 27
C7 complement component 7
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCDC109B coiled-coil domain containing 109B
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPB centromere protein B, 80kDa
CENPF centromere protein F, 350/400kDa
CENPM centromere protein M
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
CXCL12 chemokine (C-X-C motif) ligand 12
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DCXR dicarbonyl/L-xylulose reductase
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ELOVL6 ELOVL fatty acid elongase 6
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
ESR1 estrogen receptor 1
F12 coagulation factor XII (Hageman factor)
FAM64A family with sequence similarity 64, member A
FBXO5 F-box protein 5
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATA3 GATA binding protein 3
GCAT glycine C-acetyltransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2AFX H2A histone family, member X
HADH hydroxyacyl-CoA dehydrogenase
HIST1H2BK histone cluster 1, H2bk
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOPX HOP homeobox
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP4 insulin-like growth factor binding protein 4
IGHM immunoglobulin heavy constant mu
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF22 kinesin family member 22
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
LY6E lymphocyte antigen 6 complex, locus E
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
METRN meteorin, glial cell differentiation regulator
MGP matrix Gla protein
MKI67 marker of proliferation Ki-67
MRPL12 mitochondrial ribosomal protein L12
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
NBN nibrin
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEK2 NIMA-related kinase 2
NFIB nuclear factor I/B
NOP56 NOP56 ribonucleoprotein
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP62 nucleoporin 62kDa
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PBK PDZ binding kinase
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPIH peptidylprolyl isomerase H (cyclophilin H)
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRSS23 protease, serine, 23
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTTG1 pituitary tumor-transforming 1
PUF60 poly-U binding splicing factor 60KDa
PVALB parvalbumin
RACGAP1 Rac GTPase activating protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
SHCBP1 SHC SH2-domain binding protein 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMC4 structural maintenance of chromosomes 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SPDEF SAM pointed domain containing ETS transcription factor
SRSF2 serine/arginine-rich splicing factor 2
SRSF3 serine/arginine-rich splicing factor 3
SRSF6 serine/arginine-rich splicing factor 6
STMN1 stathmin 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TIMELESS timeless circadian clock
TK1 thymidine kinase 1, soluble
TMEM109 transmembrane protein 109
TMEM97 transmembrane protein 97
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TPBG trophoblast glycoprotein
TPX2 TPX2, microtubule-associated
TRIM28 tripartite motif containing 28
TRIP13 thyroid hormone receptor interactor 13
TRMT5 tRNA methyltransferase 5
TROAP trophinin associated protein
TSPAN13 tetraspanin 13
TSPAN4 tetraspanin 4
TTK TTK protein kinase
TUBB tubulin, beta class I
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
VRK1 vaccinia related kinase 1
XBP1 X-box binding protein 1
ZWINT ZW10 interacting kinetochore protein