BRD-K81709173_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

94 genes differentially expressed following the BRD-K81709173_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ADORA2B adenosine A2b receptor
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
AUTS2 autism susceptibility candidate 2
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCR1 chemokine (C-C motif) receptor 1
CD48 CD48 molecule
CD86 CD86 molecule
CLU clusterin
COLEC12 collectin sub-family member 12
CXCL14 chemokine (C-X-C motif) ligand 14
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DPYD dihydropyrimidine dehydrogenase
DSP desmoplakin
DST dystonin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
EMP1 epithelial membrane protein 1
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FGR FGR proto-oncogene, Src family tyrosine kinase
FOXG1 forkhead box G1
FSD1 fibronectin type III and SPRY domain containing 1
GIMAP4 GTPase, IMAP family member 4
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRB7 growth factor receptor-bound protein 7
HOPX HOP homeobox
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLF4 Kruppel-like factor 4 (gut)
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LMO3 LIM domain only 3 (rhombotin-like 2)
LSR lipolysis stimulated lipoprotein receptor
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MNDA myeloid cell nuclear differentiation antigen
NCF2 neutrophil cytosolic factor 2
NRGN neurogranin (protein kinase C substrate, RC3)
P3H2 prolyl 3-hydroxylase 2
PLS3 plastin 3
PPL periplakin
RIN2 Ras and Rab interactor 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SDC2 syndecan 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFTPB surfactant protein B
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TTN titin
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ALCAM activated leukocyte cell adhesion molecule
ANKRD6 ankyrin repeat domain 6
ARG2 arginase 2
CD24 CD24 molecule
CLEC11A C-type lectin domain family 11, member A
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL12 chemokine (C-X-C motif) ligand 12
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYTL1 cytokine-like 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DHRS2 dehydrogenase/reductase (SDR family) member 2
EIF5B eukaryotic translation initiation factor 5B
G0S2 G0/G1 switch 2
GAS1 growth arrest-specific 1
GPX3 glutathione peroxidase 3
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
MT1F metallothionein 1F
MT1X metallothionein 1X
MTF2 metal response element binding transcription factor 2
NEFH neurofilament, heavy polypeptide
NOLC1 nucleolar and coiled-body phosphoprotein 1
PDCD2 programmed cell death 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PNMA1 paraneoplastic Ma antigen 1
PPIF peptidylprolyl isomerase F
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TSPYL5 TSPY-like 5
VAT1 vesicle amine transport 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)