BRD-K81592585_DM-55-3 BRD-K81592585_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

84 genes differentially expressed following the BRD-K81592585_DM-55-3 BRD-K81592585_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
CDK19 cyclin-dependent kinase 19
CHI3L2 chitinase 3-like 2
CTSH cathepsin H
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FASN fatty acid synthase
FBN2 fibrillin 2
FDPS farnesyl diphosphate synthase
FKBP11 FK506 binding protein 11, 19 kDa
GLRX glutaredoxin (thioltransferase)
GSTA4 glutathione S-transferase alpha 4
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGHD immunoglobulin heavy constant delta
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGLV2-23 immunoglobulin lambda variable 2-23
INSIG1 insulin induced gene 1
IRF8 interferon regulatory factor 8
KDM5D lysine (K)-specific demethylase 5D
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METRN meteorin, glial cell differentiation regulator
MSMO1 methylsterol monooxygenase 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
NKX3-1 NK3 homeobox 1
NUPR1 nuclear protein, transcriptional regulator, 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PRAME preferentially expressed antigen in melanoma
REXO2 RNA exonuclease 2
RHOBTB3 Rho-related BTB domain containing 3
S100A2 S100 calcium binding protein A2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIP6 thyroid hormone receptor interactor 6
TSPAN13 tetraspanin 13
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ADGRL4 adhesion G protein-coupled receptor L4
AFP alpha-fetoprotein
AHSG alpha-2-HS-glycoprotein
ALB albumin
AMBP alpha-1-microglobulin/bikunin precursor
BEX4 brain expressed, X-linked 4
CLC Charcot-Leyden crystal galectin
CRABP1 cellular retinoic acid binding protein 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ESR1 estrogen receptor 1
FABP4 fatty acid binding protein 4, adipocyte
FBXL12 F-box and leucine-rich repeat protein 12
FRZB frizzled-related protein
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPC3 glypican 3
METTL7A methyltransferase like 7A
NANOG Nanog homeobox
NCAM1 neural cell adhesion molecule 1
NQO1 NAD(P)H dehydrogenase, quinone 1
OLFM1 olfactomedin 1
ORC1 origin recognition complex, subunit 1
PBX3 pre-B-cell leukemia homeobox 3
PDE2A phosphodiesterase 2A, cGMP-stimulated
PEG10 paternally expressed 10
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RBP4 retinol binding protein 4, plasma
RGS5 regulator of G-protein signaling 5
SCUBE2 signal peptide, CUB domain, EGF-like 2
SPINK1 serine peptidase inhibitor, Kazal type 1
XIST X inactive specific transcript (non-protein coding)
ZNF423 zinc finger protein 423