BRD-K81592585_DM-55-3 BRD-K81592585_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

169 genes differentially expressed following the BRD-K81592585_DM-55-3 BRD-K81592585_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP12 A kinase (PRKA) anchor protein 12
ALDOC aldolase C, fructose-bisphosphate
ANKRD10 ankyrin repeat domain 10
BEX1 brain expressed, X-linked 1
CD36 CD36 molecule (thrombospondin receptor)
CDKN2A cyclin-dependent kinase inhibitor 2A
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CRABP2 cellular retinoic acid binding protein 2
CST3 cystatin C
CTSE cathepsin E
ERP29 endoplasmic reticulum protein 29
F13A1 coagulation factor XIII, A1 polypeptide
FASN fatty acid synthase
FN1 fibronectin 1
FST follistatin
GAS1 growth arrest-specific 1
GPC3 glypican 3
GRIA2 glutamate receptor, ionotropic, AMPA 2
GYPC glycophorin C (Gerbich blood group)
HBD hemoglobin, delta
HHEX hematopoietically expressed homeobox
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IRS2 insulin receptor substrate 2
KIAA0226L KIAA0226-like
KLF6 Kruppel-like factor 6
LAMP1 lysosomal-associated membrane protein 1
LDLR low density lipoprotein receptor
LMO4 LIM domain only 4
LOX lysyl oxidase
MSLN mesothelin
NCAM1 neural cell adhesion molecule 1
NELL2 NEL-like 2 (chicken)
NMB neuromedin B
PDIA3 protein disulfide isomerase family A, member 3
PDZK1IP1 PDZK1 interacting protein 1
PENK proenkephalin
PRKCB protein kinase C, beta
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMC1A structural maintenance of chromosomes 1A
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TGFA transforming growth factor, alpha
TM4SF4 transmembrane 4 L six family member 4
TMBIM1 transmembrane BAX inhibitor motif containing 1
TNNT1 troponin T type 1 (skeletal, slow)
TSPAN7 tetraspanin 7
TXNIP thioredoxin interacting protein
UGCG UDP-glucose ceramide glucosyltransferase
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADGRF5 adhesion G protein-coupled receptor F5
ADI1 acireductone dioxygenase 1
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARMCX2 armadillo repeat containing, X-linked 2
ATF1 activating transcription factor 1
BET1 Bet1 golgi vesicular membrane trafficking protein
CCL19 chemokine (C-C motif) ligand 19
CCNE2 cyclin E2
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CEP55 centrosomal protein 55kDa
CEP57 centrosomal protein 57kDa
CETN3 centrin, EF-hand protein, 3
CHEK1 checkpoint kinase 1
CHMP4A charged multivesicular body protein 4A
CREM cAMP responsive element modulator
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRYZ crystallin, zeta (quinone reductase)
CSRP1 cysteine and glycine-rich protein 1
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL9 chemokine (C-X-C motif) ligand 9
DCN decorin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLD dihydrolipoamide dehydrogenase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DST dystonin
DYNLT3 dynein, light chain, Tctex-type 3
EBNA1BP2 EBNA1 binding protein 2
EFHD1 EF-hand domain family, member D1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FOSL2 FOS-like antigen 2
FXYD2 FXYD domain containing ion transport regulator 2
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GOLPH3 golgi phosphoprotein 3 (coat-protein)
GOLT1B golgi transport 1B
GPSM2 G-protein signaling modulator 2
HMG20B high mobility group 20B
HPRT1 hypoxanthine phosphoribosyltransferase 1
HRSP12 heat-responsive protein 12
IGFBP7 insulin-like growth factor binding protein 7
IGL immunoglobulin lambda locus
KANK1 KN motif and ankyrin repeat domains 1
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
LIMCH1 LIM and calponin homology domains 1
LUM lumican
MAP7 microtubule-associated protein 7
MET MET proto-oncogene, receptor tyrosine kinase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit
NANS N-acetylneuraminic acid synthase
NAV2 neuron navigator 2
NBN nibrin
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NFIB nuclear factor I/B
NRIP1 nuclear receptor interacting protein 1
ORC5 origin recognition complex, subunit 5
OXA1L oxidase (cytochrome c) assembly 1-like
OXCT1 3-oxoacid CoA transferase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBK PDZ binding kinase
PKP2 plakophilin 2
PRPF4 pre-mRNA processing factor 4
PSIP1 PC4 and SFRS1 interacting protein 1
PUS7 pseudouridylate synthase 7 (putative)
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RBM47 RNA binding motif protein 47
RECQL RecQ helicase-like
RIN2 Ras and Rab interactor 2
RRP1B ribosomal RNA processing 1B
S100A13 S100 calcium binding protein A13
SC5D sterol-C5-desaturase
SCGB2A2 secretoglobin, family 2A, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC25A46 solute carrier family 25, member 46
SMC2 structural maintenance of chromosomes 2
SMS spermine synthase
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOAT1 sterol O-acyltransferase 1
STAT1 signal transducer and activator of transcription 1, 91kDa
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TACSTD2 tumor-associated calcium signal transducer 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM45A transmembrane protein 45A
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TPD52 tumor protein D52
USP22 ubiquitin specific peptidase 22
ZIC1 Zic family member 1