BRD-K81473043_-666_SW620_6.0_h_0.35_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

84 genes differentially expressed following the BRD-K81473043_-666_SW620_6.0_h_0.35_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BAG3 BCL2-associated athanogene 3
BPTF bromodomain PHD finger transcription factor
CASP1 caspase 1, apoptosis-related cysteine peptidase
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEP57 centrosomal protein 57kDa
CLEC2B C-type lectin domain family 2, member B
COL1A1 collagen, type I, alpha 1
CXCL5 chemokine (C-X-C motif) ligand 5
CYB5R1 cytochrome b5 reductase 1
CYTIP cytohesin 1 interacting protein
DDIT3 DNA-damage-inducible transcript 3
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EGFR epidermal growth factor receptor
GARS glycyl-tRNA synthetase
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IGF1R insulin-like growth factor 1 receptor
IGFBP5 insulin-like growth factor binding protein 5
KLHL24 kelch-like family member 24
LAPTM4B lysosomal protein transmembrane 4 beta
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PHGDH phosphoglycerate dehydrogenase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PON3 paraoxonase 3
QPCT glutaminyl-peptide cyclotransferase
S100A8 S100 calcium binding protein A8
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TPD52 tumor protein D52
TPR translocated promoter region, nuclear basket protein
TRIM2 tripartite motif containing 2
TUBA1A tubulin, alpha 1a

decreased expression

Symbol Name
APMAP adipocyte plasma membrane associated protein
ASPH aspartate beta-hydroxylase
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
CD36 CD36 molecule (thrombospondin receptor)
CD99 CD99 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CST3 cystatin C
CXCL14 chemokine (C-X-C motif) ligand 14
CYBRD1 cytochrome b reductase 1
CYTL1 cytokine-like 1
DENND5A DENN/MADD domain containing 5A
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFHD2 EF-hand domain family, member D2
EPHA2 EPH receptor A2
F3 coagulation factor III (thromboplastin, tissue factor)
FABP4 fatty acid binding protein 4, adipocyte
FABP7 fatty acid binding protein 7, brain
FOSL1 FOS-like antigen 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GNAS GNAS complex locus
GPM6A glycoprotein M6A
HBEGF heparin-binding EGF-like growth factor
HSPA14 heat shock 70kDa protein 14
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
ITGA6 integrin, alpha 6
KLF4 Kruppel-like factor 4 (gut)
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MAT2A methionine adenosyltransferase II, alpha
NQO1 NAD(P)H dehydrogenase, quinone 1
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA2 pleckstrin homology-like domain, family A, member 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
RPP38 ribonuclease P/MRP 38kDa subunit
SLC35G2 solute carrier family 35, member G2
SOX4 SRY (sex determining region Y)-box 4
ST7 suppression of tumorigenicity 7
SYBU syntabulin (syntaxin-interacting)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
WEE1 WEE1 G2 checkpoint kinase