BRD-K81473043_-666_MCF7_6.0_h_0.35_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

65 genes differentially expressed following the BRD-K81473043_-666_MCF7_6.0_h_0.35_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
CAST calpastatin
CD24 CD24 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
COL8A2 collagen, type VIII, alpha 2
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
HK1 hexokinase 1
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD1 interferon-related developmental regulator 1
IQGAP1 IQ motif containing GTPase activating protein 1
KRT19 keratin 19, type I
LOX lysyl oxidase
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PIR pirin (iron-binding nuclear protein)
PSAT1 phosphoserine aminotransferase 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
S100A8 S100 calcium binding protein A8
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TMEM97 transmembrane protein 97
TNNT1 troponin T type 1 (skeletal, slow)
TUBA4A tubulin, alpha 4a

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
B3GNT1
BAMBI BMP and activin membrane-bound inhibitor
CAV1 caveolin 1, caveolae protein, 22kDa
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CFI complement factor I
DMD dystrophin
GRB14 growth factor receptor-bound protein 14
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
OPHN1 oligophrenin 1
PIP prolactin-induced protein
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFTN1 raftlin, lipid raft linker 1
RHOH ras homolog family member H
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
SCD5 stearoyl-CoA desaturase 5
SOX4 SRY (sex determining region Y)-box 4
SPRR2B small proline-rich protein 2B
TFPI2 tissue factor pathway inhibitor 2
XBP1 X-box binding protein 1