BRD-K81473043_-666_HEPG2_6.0_h_0.35_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

97 genes differentially expressed following the BRD-K81473043_-666_HEPG2_6.0_h_0.35_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASNS asparagine synthetase (glutamine-hydrolyzing)
AUTS2 autism susceptibility candidate 2
C3ORF14 chromosome 3 open reading frame 14
CADM1 cell adhesion molecule 1
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CBS cystathionine-beta-synthase
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC5 chloride intracellular channel 5
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
CRABP2 cellular retinoic acid binding protein 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FAM129A family with sequence similarity 129, member A
FLRT2 fibronectin leucine rich transmembrane protein 2
GARS glycyl-tRNA synthetase
GMPR guanosine monophosphate reductase
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
IFI44 interferon-induced protein 44
KLK10 kallikrein-related peptidase 10
MARS methionyl-tRNA synthetase
MDK midkine (neurite growth-promoting factor 2)
MLPH melanophilin
NPIPB3 nuclear pore complex interacting protein family, member B3
NRCAM neuronal cell adhesion molecule
NRIP1 nuclear receptor interacting protein 1
NXN nucleoredoxin
RGS10 regulator of G-protein signaling 10
RGS3 regulator of G-protein signaling 3
SEPW1 selenoprotein W, 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNX7 sorting nexin 7
SPINK1 serine peptidase inhibitor, Kazal type 1
SST somatostatin
TARS threonyl-tRNA synthetase
THBS1 thrombospondin 1
THBS4 thrombospondin 4
TNNT1 troponin T type 1 (skeletal, slow)
TUSC3 tumor suppressor candidate 3
TXNIP thioredoxin interacting protein
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
BRCA1 breast cancer 1, early onset
C11ORF71 chromosome 11 open reading frame 71
CA12 carbonic anhydrase XII
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CDC42 cell division cycle 42
CRIP1 cysteine-rich protein 1 (intestinal)
DHFR dihydrofolate reductase
EIF5 eukaryotic translation initiation factor 5
ERBB2 erb-b2 receptor tyrosine kinase 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GM2A GM2 ganglioside activator
GNAS GNAS complex locus
GPM6A glycoprotein M6A
GPX3 glutathione peroxidase 3
GRB14 growth factor receptor-bound protein 14
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IER3 immediate early response 3
ITGA6 integrin, alpha 6
LMO2 LIM domain only 2 (rhombotin-like 1)
LTF lactotransferrin
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MCOLN1 mucolipin 1
METTL7A methyltransferase like 7A
MYH11 myosin, heavy chain 11, smooth muscle
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
PEBP1 phosphatidylethanolamine binding protein 1
PIP prolactin-induced protein
PLA2G16 phospholipase A2, group XVI
PLAT plasminogen activator, tissue
RAD23B RAD23 homolog B (S. cerevisiae)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SCGB2A2 secretoglobin, family 2A, member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SORBS3 sorbin and SH3 domain containing 3
SOX4 SRY (sex determining region Y)-box 4
TAGLN transgelin
TCTA T-cell leukemia translocation altered
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)