BRD-K81418486_vorinostat_SNUC4_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

165 genes differentially expressed following the BRD-K81418486_vorinostat_SNUC4_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AKAP12 A kinase (PRKA) anchor protein 12
ALDOC aldolase C, fructose-bisphosphate
AMDHD2 amidohydrolase domain containing 2
BBX bobby sox homolog (Drosophila)
BLVRA biliverdin reductase A
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CASP7 caspase 7, apoptosis-related cysteine peptidase
CD36 CD36 molecule (thrombospondin receptor)
CGRRF1 cell growth regulator with ring finger domain 1
CORO1A coronin, actin binding protein, 1A
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
ECI2 enoyl-CoA delta isomerase 2
EGR1 early growth response 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FADS3 fatty acid desaturase 3
FAM117A family with sequence similarity 117, member A
FKBP1B FK506 binding protein 1B, 12.6 kDa
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FYN FYN proto-oncogene, Src family tyrosine kinase
G6PD glucose-6-phosphate dehydrogenase
GADD45B growth arrest and DNA-damage-inducible, beta
GCH1 GTP cyclohydrolase 1
GLRX glutaredoxin (thioltransferase)
GNAS GNAS complex locus
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H4H histone cluster 1, H4h
IGFBP5 insulin-like growth factor binding protein 5
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
KCTD5 potassium channel tetramerization domain containing 5
LGALS1 lectin, galactoside-binding, soluble, 1
LPIN1 lipin 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MAPT microtubule-associated protein tau
MLF1 myeloid leukemia factor 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MYH10 myosin, heavy chain 10, non-muscle
NEU1 sialidase 1 (lysosomal sialidase)
NOSIP nitric oxide synthase interacting protein
NPY neuropeptide Y
NRGN neurogranin (protein kinase C substrate, RC3)
OAT ornithine aminotransferase
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDGFD platelet derived growth factor D
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PEG10 paternally expressed 10
PLA2G15 phospholipase A2, group XV
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAP1GAP RAP1 GTPase activating protein
RGS10 regulator of G-protein signaling 10
RGS2 regulator of G-protein signaling 2
SCG2 secretogranin II
SCGB1D2 secretoglobin, family 1D, member 2
SCPEP1 serine carboxypeptidase 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SGCE sarcoglycan, epsilon
SGK1 serum/glucocorticoid regulated kinase 1
SKAP2 src kinase associated phosphoprotein 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SPTSSA serine palmitoyltransferase, small subunit A
SRPX sushi-repeat containing protein, X-linked
SST somatostatin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STXBP1 syntaxin binding protein 1
TACSTD2 tumor-associated calcium signal transducer 2
TBPL1 TBP-like 1
THBS2 thrombospondin 2
TSPAN7 tetraspanin 7
TUBA1A tubulin, alpha 1a
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
ZBED2 zinc finger, BED-type containing 2

decreased expression

Symbol Name
ADORA2B adenosine A2b receptor
AGR2 anterior gradient 2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANO1 anoctamin 1, calcium activated chloride channel
ANXA3 annexin A3
AQP9 aquaporin 9
ATF5 activating transcription factor 5
AUTS2 autism susceptibility candidate 2
BASP1 brain abundant, membrane attached signal protein 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BHLHE40 basic helix-loop-helix family, member e40
BTG3 BTG family, member 3
CA12 carbonic anhydrase XII
CCND1 cyclin D1
CCND2 cyclin D2
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CELF2 CUGBP, Elav-like family member 2
COA3 cytochrome c oxidase assembly factor 3
COL6A1 collagen, type VI, alpha 1
CST7 cystatin F (leukocystatin)
CTSS cathepsin S
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CYC1 cytochrome c-1
EIF5A eukaryotic translation initiation factor 5A
ERBB2 erb-b2 receptor tyrosine kinase 2
ETV1 ets variant 1
FAM57A family with sequence similarity 57, member A
FERMT1 fermitin family member 1
FOXM1 forkhead box M1
GPX2 glutathione peroxidase 2
GRWD1 glutamate-rich WD repeat containing 1
GSAP gamma-secretase activating protein
HDGF hepatoma-derived growth factor
HMGB2 high mobility group box 2
IGFBP1 insulin-like growth factor binding protein 1
IRAK1 interleukin-1 receptor-associated kinase 1
KEAP1 kelch-like ECH-associated protein 1
KIF20A kinesin family member 20A
MARCKS myristoylated alanine-rich protein kinase C substrate
MICALL1 MICAL-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO5C myosin VC
NME1 NME/NM23 nucleoside diphosphate kinase 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
OPHN1 oligophrenin 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAC8 placenta-specific 8
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
PSCA prostate stem cell antigen
PTGES prostaglandin E synthase
PWP1 PWP1 homolog (S. cerevisiae)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPL10 ribosomal protein L10
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SNRPE small nuclear ribonucleoprotein polypeptide E
SPRY2 sprouty homolog 2 (Drosophila)
STC2 stanniocalcin 2
TFF1 trefoil factor 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNS3 tensin 3
TP53 tumor protein p53
TRIB3 tribbles pseudokinase 3
UFC1 ubiquitin-fold modifier conjugating enzyme 1
USP22 ubiquitin specific peptidase 22
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
ZMYND11 zinc finger, MYND-type containing 11