BRD-K81365078_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

63 genes differentially expressed following the BRD-K81365078_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
CA12 carbonic anhydrase XII
CAST calpastatin
CLU clusterin
CSRP1 cysteine and glycine-rich protein 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
GRIA2 glutamate receptor, ionotropic, AMPA 2
HMOX1 heme oxygenase 1
IL1RN interleukin 1 receptor antagonist
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGA6 integrin, alpha 6
KLF4 Kruppel-like factor 4 (gut)
KLK11 kallikrein-related peptidase 11
KRT6A keratin 6A, type II
LCN2 lipocalin 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NDRG2 NDRG family member 2
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PI3 peptidase inhibitor 3, skin-derived
RIT1 Ras-like without CAAX 1
S100A12 S100 calcium binding protein A12
S100A2 S100 calcium binding protein A2
S100A9 S100 calcium binding protein A9
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SFN stratifin
TRIM16 tripartite motif containing 16
TSPAN7 tetraspanin 7
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
ALCAM activated leukocyte cell adhesion molecule
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASS1 argininosuccinate synthase 1
CALR calreticulin
CCNE2 cyclin E2
COL11A1 collagen, type XI, alpha 1
CPE carboxypeptidase E
CRABP1 cellular retinoic acid binding protein 1
DARS aspartyl-tRNA synthetase
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
GADD45B growth arrest and DNA-damage-inducible, beta
GPC3 glypican 3
IGL immunoglobulin lambda locus
LAMP5 lysosomal-associated membrane protein family, member 5
MATN2 matrilin 2
MXRA5 matrix-remodelling associated 5
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
POSTN periostin, osteoblast specific factor
SEC63 SEC63 homolog (S. cerevisiae)
SPINK1 serine peptidase inhibitor, Kazal type 1
THBS1 thrombospondin 1
TWIST1 twist family bHLH transcription factor 1