BRD-K81169441_cerivastatin na_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

191 genes differentially expressed following the BRD-K81169441_cerivastatin na_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACACA acetyl-CoA carboxylase alpha
ACAT2 acetyl-CoA acetyltransferase 2
ACLY ATP citrate lyase
ACSL3 acyl-CoA synthetase long-chain family member 3
ADRB2 adrenoceptor beta 2, surface
AIM1 absent in melanoma 1
ALDOC aldolase C, fructose-bisphosphate
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
C14ORF1 chromosome 14 open reading frame 1
CD9 CD9 molecule
CETN2 centrin, EF-hand protein, 2
CLIC4 chloride intracellular channel 4
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DIAPH2 diaphanous-related formin 2
EBP emopamil binding protein (sterol isomerase)
EFNB2 ephrin-B2
ELOVL5 ELOVL fatty acid elongase 5
ELOVL6 ELOVL fatty acid elongase 6
EPCAM epithelial cell adhesion molecule
FABP3 fatty acid binding protein 3, muscle and heart
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAXDC2 fatty acid hydroxylase domain containing 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FLNB filamin B, beta
FOXO3 forkhead box O3
GDI1 GDP dissociation inhibitor 1
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GREB1 growth regulation by estrogen in breast cancer 1
HMGB3 high mobility group box 3
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1L hematological and neurological expressed 1-like
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
IDI1 isopentenyl-diphosphate delta isomerase 1
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KIAA1324 KIAA1324
LAMA3 laminin, alpha 3
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MFAP5 microfibrillar associated protein 5
MSMB microseminoprotein, beta-
MSMO1 methylsterol monooxygenase 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MVD mevalonate (diphospho) decarboxylase
NMU neuromedin U
NPY1R neuropeptide Y receptor Y1
NSDHL NAD(P) dependent steroid dehydrogenase-like
PDGFA platelet-derived growth factor alpha polypeptide
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
RAP1GAP RAP1 GTPase activating protein
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SFN stratifin
SFXN3 sideroflexin 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SQLE squalene epoxidase
SREBF2 sterol regulatory element binding transcription factor 2
STAR steroidogenic acute regulatory protein
STXBP1 syntaxin binding protein 1
TM7SF2 transmembrane 7 superfamily member 2
TMEM2 transmembrane protein 2
TMEM97 transmembrane protein 97
TPM2 tropomyosin 2 (beta)
TRIB3 tribbles pseudokinase 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
VGLL4 vestigial-like family member 4

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
AHR aryl hydrocarbon receptor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDOB aldolase B, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ANGPT1 angiopoietin 1
ARHGAP29 Rho GTPase activating protein 29
ARL4C ADP-ribosylation factor-like 4C
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG2 BCL2-associated athanogene 2
BIRC5 baculoviral IAP repeat containing 5
C20ORF24 chromosome 20 open reading frame 24
CA2 carbonic anhydrase II
CCND2 cyclin D2
CCNE2 cyclin E2
CD14 CD14 molecule
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CFB complement factor B
CFH complement factor H
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHN1 chimerin 1
CP ceruloplasmin (ferroxidase)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DPYD dihydropyrimidine dehydrogenase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFHD1 EF-hand domain family, member D1
FEN1 flap structure-specific endonuclease 1
FGFR2 fibroblast growth factor receptor 2
FOXF2 forkhead box F2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GHR growth hormone receptor
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLRX glutaredoxin (thioltransferase)
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H1C histone cluster 1, H1c
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IFI44 interferon-induced protein 44
IGFBP3 insulin-like growth factor binding protein 3
ITM2C integral membrane protein 2C
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KIAA0101 KIAA0101
LIG1 ligase I, DNA, ATP-dependent
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MEA1 male-enhanced antigen 1
MXRA5 matrix-remodelling associated 5
PCNA proliferating cell nuclear antigen
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PTGIS prostaglandin I2 (prostacyclin) synthase
RFC2 replication factor C (activator 1) 2, 40kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
RND3 Rho family GTPase 3
RPA2 replication protein A2, 32kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
RTP4 receptor (chemosensory) transporter protein 4
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SAR1B secretion associated, Ras related GTPase 1B
SDC2 syndecan 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SRP19 signal recognition particle 19kDa
SSR1 signal sequence receptor, alpha
TDO2 tryptophan 2,3-dioxygenase
TFRC transferrin receptor
TMPO thymopoietin
TPD52L1 tumor protein D52-like 1
TRD T cell receptor delta locus
TRIP6 thyroid hormone receptor interactor 6
TSPAN6 tetraspanin 6
TYMS thymidylate synthetase
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
UNG uracil-DNA glycosylase
ZEB1 zinc finger E-box binding homeobox 1
ZWINT ZW10 interacting kinetochore protein