BRD-K80786583_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

382 genes differentially expressed following the BRD-K80786583_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ALAS2 5'-aminolevulinate synthase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
AZU1 azurocidin 1
BHLHE40 basic helix-loop-helix family, member e40
BRD2 bromodomain containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
CA1 carbonic anhydrase I
CARS cysteinyl-tRNA synthetase
CCNL1 cyclin L1
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
COPA coatomer protein complex, subunit alpha
CREB3L2 cAMP responsive element binding protein 3-like 2
CREM cAMP responsive element modulator
CTH cystathionine gamma-lyase
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEFA5 defensin, alpha 5, Paneth cell-specific
DFNA5 deafness, autosomal dominant 5
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ELANE elastase, neutrophil expressed
EPAS1 endothelial PAS domain protein 1
FAM60A family with sequence similarity 60, member A
FKBP14 FK506 binding protein 14, 22 kDa
FN1 fibronectin 1
FNDC3A fibronectin type III domain containing 3A
FNDC3B fibronectin type III domain containing 3B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
FTH1 ferritin, heavy polypeptide 1
FXR1 fragile X mental retardation, autosomal homolog 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GCLC glutamate-cysteine ligase, catalytic subunit
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GORASP2 golgi reassembly stacking protein 2, 55kDa
GTPBP2 GTP binding protein 2
HBD hemoglobin, delta
HDLBP high density lipoprotein binding protein
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HNRNPL heterogeneous nuclear ribonucleoprotein L
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HYOU1 hypoxia up-regulated 1
IER2 immediate early response 2
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INSR insulin receptor
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KYNU kynureninase
LARP6 La ribonucleoprotein domain family, member 6
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LRRC15 leucine rich repeat containing 15
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MFAP5 microfibrillar associated protein 5
MID1IP1 MID1 interacting protein 1
MIR22HG MIR22 host gene
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
NUCB2 nucleobindin 2
NUPL1 nucleoporin like 1
NUPR1 nuclear protein, transcriptional regulator, 1
OSER1 oxidative stress responsive serine-rich 1
PER1 period circadian clock 1
PLAUR plasminogen activator, urokinase receptor
PLIN2 perilipin 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTP4A1 protein tyrosine phosphatase type IVA, member 1
QPCT glutaminyl-peptide cyclotransferase
RANBP2 RAN binding protein 2
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
RSRC2 arginine/serine-rich coiled-coil 2
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SEC62 SEC62 homolog (S. cerevisiae)
SEC63 SEC63 homolog (S. cerevisiae)
SERP1 stress-associated endoplasmic reticulum protein 1
SERTAD2 SERTA domain containing 2
SETD5 SET domain containing 5
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SIK3 SIK family kinase 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SPAG9 sperm associated antigen 9
SQSTM1 sequestosome 1
SRGN serglycin
STC2 stanniocalcin 2
SWAP70 SWAP switching B-cell complex 70kDa subunit
TARS threonyl-tRNA synthetase
TDO2 tryptophan 2,3-dioxygenase
TLK2 tousled-like kinase 2
TMEM87A transmembrane protein 87A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIM16 tripartite motif containing 16
TRIM2 tripartite motif containing 2
TSKU tsukushi, small leucine rich proteoglycan
TTC17 tetratricopeptide repeat domain 17
TXNRD1 thioredoxin reductase 1
UFM1 ubiquitin-fold modifier 1
VEGFA vascular endothelial growth factor A
VIM vimentin
VTCN1 V-set domain containing T cell activation inhibitor 1
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
WNT5A wingless-type MMTV integration site family, member 5A
WSB1 WD repeat and SOCS box containing 1
YARS tyrosyl-tRNA synthetase
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein
ZNF165 zinc finger protein 165
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ABHD2 abhydrolase domain containing 2
ACOT7 acyl-CoA thioesterase 7
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADI1 acireductone dioxygenase 1
ADIRF adipogenesis regulatory factor
AKT1 v-akt murine thymoma viral oncogene homolog 1
ASF1B anti-silencing function 1B histone chaperone
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
B3GNT1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C14ORF2 chromosome 14 open reading frame 2
C7 complement component 7
CACYBP calcyclin binding protein
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CBFB core-binding factor, beta subunit
CBX3 chromobox homolog 3
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPM centromere protein M
CENPN centromere protein N
CETN2 centrin, EF-hand protein, 2
CHEK2 checkpoint kinase 2
CHRDL1 chordin-like 1
CKLF chemokine-like factor
CLTB clathrin, light chain B
COMMD8 COMM domain containing 8
COX7B cytochrome c oxidase subunit VIIb
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous)
CRYZ crystallin, zeta (quinone reductase)
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSK c-src tyrosine kinase
CTSH cathepsin H
CXCL12 chemokine (C-X-C motif) ligand 12
CYC1 cytochrome c-1
DCK deoxycytidine kinase
DCTPP1 dCTP pyrophosphatase 1
DCXR dicarbonyl/L-xylulose reductase
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYSL2 dihydropyrimidinase-like 2
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP2 epithelial membrane protein 2
ETFB electron-transfer-flavoprotein, beta polypeptide
FAM64A family with sequence similarity 64, member A
FANCI Fanconi anemia, complementation group I
FEN1 flap structure-specific endonuclease 1
FKBP3 FK506 binding protein 3, 25kDa
FMO2 flavin containing monooxygenase 2 (non-functional)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GATA3 GATA binding protein 3
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GTF2H5 general transcription factor IIH, polypeptide 5
HADH hydroxyacyl-CoA dehydrogenase
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HIST1H4C histone cluster 1, H4c
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSBP1 heat shock factor binding protein 1
ICAM3 intercellular adhesion molecule 3
IFITM2 interferon induced transmembrane protein 2
IFRD2 interferon-related developmental regulator 2
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ISOC1 isochorismatase domain containing 1
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
LAGE3 L antigen family, member 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LPCAT1 lysophosphatidylcholine acyltransferase 1
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LY6E lymphocyte antigen 6 complex, locus E
LYPLA1 lysophospholipase I
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MATN2 matrilin 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
METRN meteorin, glial cell differentiation regulator
MGST2 microsomal glutathione S-transferase 2
MRPL12 mitochondrial ribosomal protein L12
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MXRA7 matrix-remodelling associated 7
MYCBP MYC binding protein
NAE1 NEDD8 activating enzyme E1 subunit 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPD3 non-SMC condensin II complex, subunit D3
NDC80 NDC80 kinetochore complex component
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NDUFA4 NDUFA4, mitochondrial complex associated
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NR2F2 nuclear receptor subfamily 2, group F, member 2
NSL1 NSL1, MIS12 kinetochore complex component
NUTF2 nuclear transport factor 2
OIP5 Opa interacting protein 5
OLFM1 olfactomedin 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PARPBP PARP1 binding protein
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PEBP1 phosphatidylethanolamine binding protein 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS23 protease, serine, 23
PSCA prostate stem cell antigen
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTTG1 pituitary tumor-transforming 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RBP1 retinol binding protein 1, cellular
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
RRM2 ribonucleotide reductase M2
S100A13 S100 calcium binding protein A13
SCP2 sterol carrier protein 2
SEPW1 selenoprotein W, 1
SIVA1 SIVA1, apoptosis-inducing factor
SKP1 S-phase kinase-associated protein 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMC2 structural maintenance of chromosomes 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SNRPG small nuclear ribonucleoprotein polypeptide G
SNX10 sorting nexin 10
SPC25 SPC25, NDC80 kinetochore complex component
SPINK1 serine peptidase inhibitor, Kazal type 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
STRA13 stimulated by retinoic acid 13
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SUMO3 small ubiquitin-like modifier 3
SYNM synemin, intermediate filament protein
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TFF1 trefoil factor 1
THBS1 thrombospondin 1
THYN1 thymocyte nuclear protein 1
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TK1 thymidine kinase 1, soluble
TMEM106C transmembrane protein 106C
TMEM109 transmembrane protein 109
TMEM126B transmembrane protein 126B
TMEM14A transmembrane protein 14A
TMEM160 transmembrane protein 160
TMEM97 transmembrane protein 97
TMPO thymopoietin
TMX1 thioredoxin-related transmembrane protein 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIP13 thyroid hormone receptor interactor 13
TSPAN4 tetraspanin 4
TSPAN6 tetraspanin 6
TSPO translocator protein (18kDa)
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2N ubiquitin-conjugating enzyme E2N
UBL4A ubiquitin-like 4A
UNG uracil-DNA glycosylase
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
VRK1 vaccinia related kinase 1
WDR61 WD repeat domain 61
WWP1 WW domain containing E3 ubiquitin protein ligase 1
ZNF185 zinc finger protein 185 (LIM domain)
ZWINT ZW10 interacting kinetochore protein