BRD-K80786583_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

142 genes differentially expressed following the BRD-K80786583_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADM adrenomedullin
ARID5B AT rich interactive domain 5B (MRF1-like)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BCL3 B-cell CLL/lymphoma 3
BHLHE40 basic helix-loop-helix family, member e40
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C5AR1 complement component 5a receptor 1
C6ORF48 chromosome 6 open reading frame 48
CA12 carbonic anhydrase XII
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CELF2 CUGBP, Elav-like family member 2
CHMP4A charged multivesicular body protein 4A
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DHRS3 dehydrogenase/reductase (SDR family) member 3
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EPHA3 EPH receptor A3
FAM129A family with sequence similarity 129, member A
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GSE1 Gse1 coiled-coil protein
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFRD1 interferon-related developmental regulator 1
INHBE inhibin, beta E
IRS2 insulin receptor substrate 2
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JUN jun proto-oncogene
JUND jun D proto-oncogene
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MBNL2 muscleblind-like splicing regulator 2
MDK midkine (neurite growth-promoting factor 2)
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MED13 mediator complex subunit 13
MNT MAX network transcriptional repressor
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO10 myosin X
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPR1 nuclear protein, transcriptional regulator, 1
OXTR oxytocin receptor
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PDLIM5 PDZ and LIM domain 5
PHLDA2 pleckstrin homology-like domain, family A, member 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTX3 pentraxin 3, long
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RNMT RNA (guanine-7-) methyltransferase
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
TFF3 trefoil factor 3 (intestinal)
TLK2 tousled-like kinase 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TREM1 triggering receptor expressed on myeloid cells 1
TRIB3 tribbles pseudokinase 3
TSKU tsukushi, small leucine rich proteoglycan
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
YARS tyrosyl-tRNA synthetase
ZFP36 ZFP36 ring finger protein
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
ANXA6 annexin A6
B3GNT1
CALD1 caldesmon 1
CCNB1 cyclin B1
CDC25A cell division cycle 25A
COPS7A COP9 signalosome subunit 7A
CRYZ crystallin, zeta (quinone reductase)
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP1 cysteine and glycine-rich protein 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EMP2 epithelial membrane protein 2
FHL1 four and a half LIM domains 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
HRSP12 heat-responsive protein 12
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
KRT13 keratin 13, type I
KRT19 keratin 19, type I
MCAM melanoma cell adhesion molecule
MXRA7 matrix-remodelling associated 7
NNMT nicotinamide N-methyltransferase
NUP107 nucleoporin 107kDa
NUP85 nucleoporin 85kDa
OLFM4 olfactomedin 4
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PXDN peroxidasin
RRM2 ribonucleotide reductase M2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRSF7 serine/arginine-rich splicing factor 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
TBC1D16 TBC1 domain family, member 16
TPM1 tropomyosin 1 (alpha)
TPM4 tropomyosin 4
VCAM1 vascular cell adhesion molecule 1