BRD-K80700417_SGI-1776_A549_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

39 genes differentially expressed following the BRD-K80700417_SGI-1776_A549_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMDEC1 ADAM-like, decysin 1
ALDOC aldolase C, fructose-bisphosphate
COLEC12 collectin sub-family member 12
DHCR24 24-dehydrocholesterol reductase
DHDDS dehydrodolichyl diphosphate synthase
DUSP4 dual specificity phosphatase 4
ELOVL6 ELOVL fatty acid elongase 6
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MSMO1 methylsterol monooxygenase 1
NUPR1 nuclear protein, transcriptional regulator, 1
PHYH phytanoyl-CoA 2-hydroxylase
RAP1GAP RAP1 GTPase activating protein
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SETBP1 SET binding protein 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SQLE squalene epoxidase
TLR4 toll-like receptor 4
TRIB2 tribbles pseudokinase 2
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
GRWD1 glutamate-rich WD repeat containing 1
GTPBP8 GTP-binding protein 8 (putative)
KRT15 keratin 15, type I
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MYCBP MYC binding protein
PEG10 paternally expressed 10
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
RGS4 regulator of G-protein signaling 4
S100A7 S100 calcium binding protein A7